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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Florian Krammer‏Verified account @florian_krammer 3 Jan 2021

      1) If we want to generate difficult viral escape mutants in the lab (e.g. for epitope mapping), we subject the virus to low antibody pressure and then slowly move up. A little bit like after one vaccine dose. I think it would be good to give the second dose as soon as possible.

      146 replies 2,103 retweets 5,875 likes
      Show this thread
    2. Alex Merz‏ @Merz 3 Jan 2021
      Replying to @florian_krammer

      @zeynep

      1 reply 0 retweets 5 likes
      zeynep tufekci‏Verified account @zeynep 3 Jan 2021
      Replying to @Merz @florian_krammer

      Great to hear Florian thinks 12 weeks isn't a big problem—which I heard from many in the field which, as I said, I am not in a position to judge but the number of experts saying that is reassuring. I think everyone agrees boosters as soon as possible is a good idea.

      10:04 AM - 3 Jan 2021
      • 4 Retweets
      • 63 Likes
      • Leona Lee Area Child Psychiatrist Homer Solstice 🌞 ☕️ Tynan 🍵 Nora Rawn Gillian C Lady Xoc🐭 🇺🇸 the straight thru crew Joseph Burns
      11 replies 4 retweets 63 likes
        1. New conversation
        2. Alex Merz‏ @Merz 3 Jan 2021
          Replying to @zeynep @florian_krammer

          This assumes that 12 weeks actually turns out to mean 12 weeks. I remain skeptical.

          1 reply 0 retweets 7 likes
        3. Vanessa Lui‏ @vzlui 3 Jan 2021
          Replying to @Merz @zeynep @florian_krammer

          My father-in-law is in his 80s. Would a schedule be fixed for someone in his age group? Or would it depend on supply chain issues?

          1 reply 0 retweets 0 likes
        4. Show replies
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          zeynep tufekci Retweeted Keith Klugman

          Did you see tweets of Keith Klugman of Gates? https://twitter.com/findingpneumo/status/1344268340857081858 … I had forgotten to flag them or you (you had mentioned being interested in Gates Foundation approach).

          zeynep tufekci added,

          Keith Klugman @findingpneumo
          Way to go UK vaccine advisory committee - 1st doses protect more people using the three EUA vaccines in US or UK than do 2nd doses - limited supply in US allows excess deaths by restricting first doses of covid vaccines - 2nd doses are still valuable but can and should be delayed https://twitter.com/PeterHorby/status/1344190491781443585 …
          2 replies 0 retweets 7 likes
        3. zeynep tufekci‏Verified account @zeynep 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          zeynep tufekci Retweeted Keith Klugman

          Also:https://twitter.com/findingpneumo/status/1339556859473227778 …

          zeynep tufekci added,

          Keith Klugman @findingpneumo
          First doses of Pfizer/Moderna vaccines are 90%+ effective after 14 days. Most high risk lives will be saved by giving all these limited early supplies of vaccine as first doses - second doses can be given later if first dose effectiveness wanes or when supply improves
          2 replies 0 retweets 3 likes
        4. Show replies
        1. New conversation
        2. Confused Mathmo‏ @confusedmathmo 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          He said *might not be* a big problem

          1 reply 0 retweets 6 likes
        3. Alex Merz‏ @Merz 3 Jan 2021
          Replying to @confusedmathmo @zeynep @florian_krammer

          Right. @zeynep’s reading of this thread is not how I read it.

          1 reply 0 retweets 3 likes
        4. Show replies
        1. Craig Kaplan‏ @TriggerLoop 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          I think what he has said is that high circulation is likely a potential problem. Meaning, we just don't really have a lot of vaccination campaigns operating in this very dangerous environment- high circulating virus.

          0 replies 0 retweets 9 likes
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        1. New conversation
        2. George Bon Jovi Washington‏ @JasonRussell1 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          That is absolutely not what he said. Re-read his comments above. He says he does not KNOW that it will be a big problem but immediately says “minimize the interval”

          1 reply 0 retweets 36 likes
        3. zeynep tufekci‏Verified account @zeynep 3 Jan 2021
          Replying to @JasonRussell1 @Merz @florian_krammer

          I am not and I cannot argue with Florian! Not my area at all! There are immunologists who think other things on this. I'm just pointing out that I haven't encountered anyone who doesn't think we shouldn't "minimize the interval."

          2 replies 1 retweet 6 likes
        4. Show replies
        1. Christoph Tavan‏ @ctavan 3 Jan 2021
          Replying to @zeynep @Merz @florian_krammer

          Christoph Tavan Retweeted Florian Krammer

          Did you see the last tweet of the thread? That doesn’t sound like @florian_krammer is a huge proponent of delaying the second shot.https://twitter.com/florian_krammer/status/1345792311737905157 …

          Christoph Tavan added,

          Florian KrammerVerified account @florian_krammer
          4) It also depends on how much virus is circulating. If virus circulation is low, the 12 week window might not be a big problem. But if virus circulation is sky high (like right now in the UK), it is not a good idea. My 2 cents.
          Show this thread
          0 replies 0 retweets 5 likes
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