1) If we want to generate difficult viral escape mutants in the lab (e.g. for epitope mapping), we subject the virus to low antibody pressure and then slowly move up. A little bit like after one vaccine dose. I think it would be good to give the second dose as soon as possible.
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This assumes that 12 weeks actually turns out to mean 12 weeks. I remain skeptical.
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My father-in-law is in his 80s. Would a schedule be fixed for someone in his age group? Or would it depend on supply chain issues?
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Did you see tweets of Keith Klugman of Gates? https://twitter.com/findingpneumo/status/1344268340857081858 … I had forgotten to flag them or you (you had mentioned being interested in Gates Foundation approach).
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He said *might not be* a big problem
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Right.
@zeynep’s reading of this thread is not how I read it. - Show replies
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I think what he has said is that high circulation is likely a potential problem. Meaning, we just don't really have a lot of vaccination campaigns operating in this very dangerous environment- high circulating virus.
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That is absolutely not what he said. Re-read his comments above. He says he does not KNOW that it will be a big problem but immediately says “minimize the interval”
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I am not and I cannot argue with Florian! Not my area at all! There are immunologists who think other things on this. I'm just pointing out that I haven't encountered anyone who doesn't think we shouldn't "minimize the interval."
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Did you see the last tweet of the thread? That doesn’t sound like
@florian_krammer is a huge proponent of delaying the second shot.https://twitter.com/florian_krammer/status/1345792311737905157 …Thanks. Twitter will use this to make your timeline better. UndoUndo
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