Not many. A few visible ones.
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Yes, they're thoughtful. And the more thoughtful they are, the less certain.
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Again, there's damned little data to get ahead /of/.
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This pushback is necessary because of armchair vaccinologists like Nate Silver.
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Also worth noting: not many of the scientists pushing a single dose regimen have substantial and specific prior experience in human vaccine development. Even if they are virologists or immunologists.
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I have only seen one scientist with actual vaccine development experience weigh in on this and they were on the side of delayed dosage
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halvorz ¯\_(ツ)_/¯ Retweeted halvorz ¯\_(ツ)_/¯
I've been looking for more but so far it's been frustratingly sparsehttps://twitter.com/halvorz/status/1345180640359182337 …
halvorz ¯\_(ツ)_/¯ added,
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coming to the conclusion that vaccinologists need to be More Online
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Again, I cannot resolve the debate within that field (except to keep calling for data collection) but I disagree a bit with Alex. The people with deep/appropriate expertise calling for delaying the booster aren't that few. That said, very thoughtful/leading people also disagree.
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There's a very significant sampling bias here.
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Well, if we had started a placebo/booster in November when the signal emerged, we'd be halfway to a better answer. I realize it's not easy, but given the stakes the best answers are speed up production (make the trade-off moot) and collect data (make the trade-off informed).
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I don't think anyone thought that the mRNA vaccines would show the kind of protection that they have so far shown. The concern was always that the vaccines would show more marginal effectiveness and trial design was driven by concerns that they'd be underpowered.
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And there's also the issue that participants were consented for the trials-as-conducted. A change in design as you suggest would have required that everyone be re-consented.
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