Meaning that at present we have one set of evidence-based options (prime + boost for multiple vaccines, not mixed).
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There's a very significant sampling bias here.
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Well, if we had started a placebo/booster in November when the signal emerged, we'd be halfway to a better answer. I realize it's not easy, but given the stakes the best answers are speed up production (make the trade-off moot) and collect data (make the trade-off informed).
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The worst case scenario is that we do this, but don't collect data. If there is a significant downside (like very rapid waning), we should monitor. The numbers on the side of rapid mass vaccination aren't minor either, but public trust is crucial, and that requires transparency.
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Trying to think if I've seen a *single* BIPOC scientist with relevant expertise speak out in support of single-dosing. Coming up empty.
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yes, it is absolutely far from clear, agreed
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