while i wasn't expecting this to happen this early or this catastrophically, *IT WAS GOING TO HAPPEN*. we can yell at each other over what is optimal until we are blue in the face & we all hate each other for no reason, or...
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...we can accept that we are in an out-of-control pandemic where there is, on average right now one person dying of
#COVIDー19 somewhere in this world every *seven seconds*, realize that delaying doses is fundamentally not immunologically unsound, and therefore...1 reply 5 retweets 42 likesShow this thread -
look, i get that clinical trials are hard. i really do. trust me on this. & i get that it's important to prioritize ones that are likely to produce results that are vitally important right now.
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but i'd say when random world gov'ts are trying this sort of stuff w/o a trial, b/c the situation is so dire *the entire medical system is about to collapse in London right now*, your hand is a bit forced. to say nothing of countries that can only afford 1 dose/person this year.
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because guess what? immunologically it makes sense that it would work. in fact, it stands to reason (& it's interesting comparing the immunologists/vaccinologists on my TL to the virologists) that it will work *better*.
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and if everyone's fears are realized & it doesn't? well here's some nice hard data to stop anyone else from trying this, from very early on in the world vaccination schedule, that's a heck of a lot more convincing if you need to stop someone like BoJo.
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a few final asides: if you seroconvert & class-switch to IgG that means you've had a T_{FH}/B-cell germinal center response, which means that yes, you have developed memory B cells to that antigen. which survive decades.
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i don't understand why i still keep hearing the whole "immunity fading" argument (and after TWELVE WEEKS?!? please show me an example of that in the literature, i tried really hard to find that the past two days w/no success).
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i thought after
@jbloom_lab demonstrated that reinfection to HCoVs was due to *antigenic drift* & not like when CoV-specific memory B cells inexplicably decide to take a vacation that year, i'd stop hearing that repeated so often...3 replies 6 retweets 36 likesShow this thread -
...particularly when it does not work this way for any other of our vaccines that are currently on the market. some references: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947622/pdf/nihms-556211.pdf … / https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947622/pdf/nihms-556211.pdf … / https://linkinghub.elsevier.com/retrieve/pii/S1074-7613(00)80541-5 … / https://www.nejm.org/doi/10.1056/NEJMoa066092 … /https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213050/ …
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Is there any other vaccine with a three week booster schedule? Most of what I know of recommends four weeks as a minimum. (I think Japanese encephalitis vaccine can be given with a shorter interval but it is also regularly given at four weeks).
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Replying to @zeynep
i tried really hard to find one that had a shorter minimum than 4 weeks & Japanese encephalitis was the only one i could find. that's minimum. absolutely nothing w/a recommend or a maximum less than a month. if anyone else knows of one, i'd be happy to hear about it!
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Replying to @wanderer_jasnah
Yeah, me too. I looked high and low, and IXIARO for JE was the only one I found.
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