Both! The mixing of AZ with Sputnik is, rightly, the subject of a new trial.
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Replying to @ArisKatzourakis
This may not have enough data because it is presented as an alternative to not offering any booster at all so may not have a sample size with power. Do you think it should be trialed anyway? Seems like something to avoid except as desperate measure? (Agree they should track).
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Replying to @zeynep
It seems doubly worrying in some ways if it will be deployed on edge cases that are unlikely to return. Hence there will be no data collected on this.
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Replying to @ArisKatzourakis
Yes they should track if they do it, even rarely. That said, they had a real trial planned on this. (Not because of supply—to see if it was better.) I’ll track down what happened. That’s what I was wondering, why is there an expectation it might be better?https://www.theguardian.com/world/2020/dec/08/covid-mixed-vaccine-trial-likely-to-begin-in-uk-next-month …
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Replying to @zeynep @ArisKatzourakis
In early December, the UK task force said that it was going to trial various combinations to see if it induced heterologous prime-boost. (Again different than last-resort scenario in guidelines). I was just wondering if you think that’s a high priority for a trial?
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Replying to @andrew_croxford @ArisKatzourakis
That’s what I’m trying to understand. Is there an immunological reason to expect a significant upside? Or is it a supply chain or logistics issue because non-mRNA vaccines are bottlenecked? Poor countries aren’t getting much anytime soon plus their cold-chain is hard.
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I could imagine a heterologous boost being useful for the Oxford vaccine given concerns over vector immunity. Don’t see any potential upside for mRNA vaccines.
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Right. But UK apparently has a trial planned already. And a lot of these trials are already happening in LMIC countries anyway. Thank you and have a great weekend!
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