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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      For the Ox/AZ vaccine, it's fairly simple. The trial demonstrated efficacy at a range of dose intervals. Antibody responses after the boost were significantly stronger with longer intervals - see table 3.https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-healthcare-professionals-on-covid-19-vaccine-astrazeneca …

      9 replies 72 retweets 301 likes
      Show this thread
    2. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      (so in response to @drmarkporter's point, higher immune responses with a longer interval is proven & now public. I haven't seen a similar analysis for efficacy against disease but the data exists and I suspect the regulators & JCVI committee have)

      6 replies 27 retweets 192 likes
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    3. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      For Pfizer, there isn't direct evidence of efficacy with a >3wk interval. But as widely publicised, efficacy in the period from 14 days after first dose to 21 days is high.pic.twitter.com/2f6QPyMg9a

      10 replies 43 retweets 203 likes
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    4. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      Can we extrapolate from this to a longer interval? It's a judgment call. On one hand is evidence-based medicine's scepticism of anything not directly proven 'beyond reasonable doubt' in an RCT; on the other is a 'balance of probabilities' approach based upon the biology.

      11 replies 37 retweets 259 likes
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    5. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      Based upon the biology, I'd eat my hat if the Pfizer vaccine is substantially less effective with a longer dose interval. Most vaccines induce stronger immune responses with longer intervals. A couple of examples below. There are more.pic.twitter.com/pxJTqjchpz

      38 replies 139 retweets 527 likes
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    6. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      Regimes like the Ox/AZ use the same adenoviral vector to prime & boost so face 'anti-vector immunity' (immunity from the first dose to the viral 'postman' which must delivers the spike protein 'message' for the boost). This favours longer intervals specifically for Ad/Ad but...

      1 reply 17 retweets 151 likes
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    7. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      ...the above shows that longer intervals are better for regimes with different viral vectors, DNA priming, inactivated virus boosting - this isn't just an adeno effect. It's v rare for a 3wk interval to give stronger responses than 8+ wks (I can't think of examples, can you?)

      5 replies 22 retweets 165 likes
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    8. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      Mechanistically, at 3w, the immune response to prime isn't complete- it hasn't yet produced all the memory B cells which give the best response to the boost. Once they are made, the memory cells last years! They won't forget how to respond to a boost in a few months.

      7 replies 28 retweets 211 likes
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    9. Sandy Douglas‏ @sandyddouglas 1 Jan 2021

      I appreciate mechanistic arguments often prove to be wrong, and RCT evidence with Pfizer at longer intervals should definitely be produced ASAP... but as @zeynep has written in an excellent article today: https://www.theatlantic.com/science/archive/2020/12/virus-mutation-catastrophe/617531/ …pic.twitter.com/NKMQGHorf8

      11 replies 76 retweets 374 likes
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    10. jayne hamilton‏ @JH_NE2 2 Jan 2021
      Replying to @sandyddouglas @zeynep

      What is your opinion of the government's plan to use a different manufacturer for the second corona virus does, as explained in the NY times? Britain Opts for Mix-and-Match Vaccinations, Confounding Expertshttps://www.nytimes.com/2021/01/01/health/coronavirus-vaccines-britain.html?smid=tw-share …

      1 reply 0 retweets 0 likes
      zeynep tufekci‏Verified account @zeynep 2 Jan 2021
      Replying to @JH_NE2 @sandyddouglas

      zeynep tufekci Retweeted zeynep tufekci

      https://twitter.com/zeynep/status/1345228987379949569 …

      zeynep tufekci added,

      zeynep tufekciVerified account @zeynep
      Replying to @ArisKatzourakis
      It seems to be only about edge cases, not about a strategy of mix and match. (Someone shows up, they may not be likely to return, the first type is unknown. The guidance is about whether to withhold booster, and notes lack of interchangeability.) I read the full guidelines. pic.twitter.com/AZDt34metl
      6:51 AM - 2 Jan 2021
      0 replies 0 retweets 0 likes

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