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zeynep tufekci
zeynep tufekci
zeynep tufekci
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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 19 Dec 2020

      Also: there are powerful politicians advocating for single dose *without a trial* (no!) and some will miss the booster (they shouldn't but always happens). Evidence on durability/effect would allow better decisions on resource allocation on this question. Resources matter.

      4 replies 11 retweets 151 likes
      Show this thread
    2. zeynep tufekci‏Verified account @zeynep 19 Dec 2020

      Some raised concerns this op-ed might lead people to skip dose. I disagree and that's the kind of thing I think most about. I think getting ahead of an idea (already out there) with potential downside/risk and putting it proper context is the way to *fight* that risk. Will write!

      8 replies 11 retweets 182 likes
      Show this thread
    3. zeynep tufekci‏Verified account @zeynep 20 Dec 2020

      zeynep tufekci Retweeted Keith Klugman

      Keith Klugman weighs in. (Dr. Klugman is the "past president of the International Society of Infectious Diseases and a past chair of the International Board of the American Society for Microbiology" among other positions/honors, now at Gates Foundation).https://twitter.com/findingpneumo/status/1339556859473227778 …

      zeynep tufekci added,

      Keith Klugman @findingpneumo
      First doses of Pfizer/Moderna vaccines are 90%+ effective after 14 days. Most high risk lives will be saved by giving all these limited early supplies of vaccine as first doses - second doses can be given later if first dose effectiveness wanes or when supply improves
      3 replies 54 retweets 200 likes
      Show this thread
    4. zeynep tufekci‏Verified account @zeynep 20 Dec 2020

      Too often what feels like "expert/science consensus"ish is actually a few Twitter people with lots of followers. (NOT ME lol!) when, in reality, there is a real debate within the scientific community—but then media leans on the high-profile Twitter experts and make it worse.

      8 replies 57 retweets 444 likes
      Show this thread
    5. zeynep tufekci‏Verified account @zeynep 20 Dec 2020

      zeynep tufekci Retweeted Keith Klugman

      Also, journalists, it's extra effort but please seek people like Dr. Klugman—leading the field, lifetime in public health & vaccines—for expert commentary on complex matters. Twitter has its uses but it favors talent for snark and subtweets over substance.https://twitter.com/findingpneumo/status/1339556859473227778 …

      zeynep tufekci added,

      Keith Klugman @findingpneumo
      First doses of Pfizer/Moderna vaccines are 90%+ effective after 14 days. Most high risk lives will be saved by giving all these limited early supplies of vaccine as first doses - second doses can be given later if first dose effectiveness wanes or when supply improves
      3 replies 27 retweets 284 likes
      Show this thread
    6. zeynep tufekci‏Verified account @zeynep 20 Dec 2020

      Not saying everyone on Twitter is like that (of course not) or that journalists should go find people who agree with a particular view. But very often what looks clear or binary to the Twitter-verse is not & that complexity is reflected in the field in way social media does not.

      3 replies 11 retweets 114 likes
      Show this thread
    7. zeynep tufekci‏Verified account @zeynep 23 Dec 2020

      Two more (pretty senior) scholars (one is a former associate director of NIH) are advocating for modifying vaccine roll-out—they suggest delaying second dose. Less Twitter dunking, more constructive effort to figure out how to test this would be excellent.https://www.medpagetoday.com/infectiousdisease/covid19/90358 …

      2 replies 26 retweets 118 likes
      Show this thread
    8. zeynep tufekci‏Verified account @zeynep 23 Dec 2020

      zeynep tufekci Retweeted The Poisonous Euros Atmosphere Fan

      Example of how polarization and Twitter dunking makes everything worse. She doesn't like Blair (fine) but she has no idea about the topic either. But it's fun to dunk on Blair! And why is Blair talking about this? He's a politician. That's what they do.https://twitter.com/DawnHFoster/status/1341724700301549569 …

      zeynep tufekci added,

      The Poisonous Euros Atmosphere FanVerified account @DawnHFoster
      Tony Blair has for no reason anyone can fathom, suggested giving people half the recommended vaccine dosage, and mercifully everyone’s agreed to ignore him pic.twitter.com/b8OxXHGZof
      25 replies 39 retweets 306 likes
      Show this thread
    9. zeynep tufekci‏Verified account @zeynep 23 Dec 2020

      One reaction I see is a lot of wagon-circling and how-dare-you indignation. I wouldn't even mind it for some topics if it had a chance of working! It's the 21st century! It has no chance of working! Have to be out there engaging the ideas—if they think it's good/bad/terrible+how.

      3 replies 4 retweets 71 likes
      Show this thread
    10. zeynep tufekci‏Verified account @zeynep 31 Dec 2020

      zeynep tufekci Retweeted Bob Wachter

      Adding to the thread, thoughts from Bob Wachter, chair of the UCSF Dept of Medicine on dosing strategy. (By the way, @bob_wachter's chronicles and virtual "grand rounds" are an amazing, living history of the pandemic).https://twitter.com/Bob_Wachter/status/1344667661246992385 …

      zeynep tufekci added,

      Bob WachterVerified account @Bob_Wachter
      Taken together, if we have vaccine doses to distribute in Jan-Apr, it seems increasingly evident that a strategy of getting as many people (particularly high-risk) their first shot ASAP will save far more lives than sticking with the two shot plan. (6/7)
      Show this thread
      4 replies 19 retweets 83 likes
      Show this thread
      zeynep tufekci‏Verified account @zeynep 31 Dec 2020

      Also, to be clear: our own op-ed advocated for immediate single-dose trials and resources/funding for it. A lot has happened since then, and many countries are forging ahead, it seems, with at least spacing boosters. That part is not mine to comment except: PLEASE COLLECT DATA.

      8:16 AM - 31 Dec 2020
      • 9 Retweets
      • 74 Likes
      • Graham Webster Jeff Davis🇺🇸(Dude) Trusted Source Myrrh Zachary Wefel Melody Crowder-Meyer Dine Alone bobbi barnett JGV
      2 replies 9 retweets 74 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 31 Dec 2020

          There are very obvious reasons why some countries are doing what they are, and there are also obvious and important cautions people are expressing. The worst case scenario is not measuring which has now turned into a natural experiment. If we measure, we can respond either way.

          2 replies 13 retweets 84 likes
          Show this thread
        3. zeynep tufekci‏Verified account @zeynep 3 Jan 2021

          An op-ed from @Bob_Wachter (chair of UCSF Dept of Medicine) and @ashishkjha (dean of SPH at Brown). https://twitter.com/Bob_Wachter/status/1345741327330263042 …pic.twitter.com/KCQPer2SsV

          4 replies 23 retweets 87 likes
          Show this thread
        4. zeynep tufekci‏Verified account @zeynep 3 Jan 2021

          zeynep tufekci Retweeted Prof. Akiko Iwasaki

          Also see this thread by one of the country's leading virologists on why she thinks we should delay the boosters in order to increase early coverage. (Disclosure: the article she's linking to about the risks of increased transmissibility is mine)https://twitter.com/VirusesImmunity/status/1345086669607890945 …

          zeynep tufekci added,

          Prof. Akiko IwasakiVerified account @VirusesImmunity
          My first tweet of 2021 is going to be about 1 dose vs. 2 dose vaccine. I have tweeted in the past of the immunological advantages of a 2 dose vaccine. However, given the enhanced transmission variants on the rise, we need a modified strategy. (1/n) https://www.theatlantic.com/science/archive/2020/12/virus-mutation-catastrophe/617531/ …
          Show this thread
          3 replies 9 retweets 62 likes
          Show this thread
        5. zeynep tufekci‏Verified account @zeynep 3 Jan 2021

          zeynep tufekci Retweeted Adam Kucharski

          Do note that with exponential growth, more *is* very different. If a location had an R just below 1, and if the new variant tips it just over 1—with the same policies—the difference isn't minor. It's the difference between decline and uncontrolled spread.https://twitter.com/AdamJKucharski/status/1345714389329051663 …

          zeynep tufekci added,

          Adam KucharskiVerified account @AdamJKucharski
          Next, suppose control can get R=0.8. In this scenario, 50% increase in transmission (R=1.2) tips epidemic into exponential growth. So we go from declining outbreak to one that sweeps uncontrolled through population. Hence 50% increase could mean many many fold more infections. 3/
          Show this thread
          2 replies 23 retweets 95 likes
          Show this thread
        6. zeynep tufekci‏Verified account @zeynep 3 Jan 2021

          I wrote this article (on New Years Eve!) because I was seeing so much media & even public health officials inappropriately reassure the public that the "new variant isn't more deadly." Technically correct but profoundly misleading about the real threat. https://www.theatlantic.com/science/archive/2020/12/virus-mutation-catastrophe/617531/ …pic.twitter.com/93Py6foXvO

          8 replies 37 retweets 143 likes
          Show this thread
        7. zeynep tufekci‏Verified account @zeynep 4 Jan 2021

          Another article advocating for an immediate trial for what happens when/if the booster is delayed, by @peterbachmd of Sloan-Kettering. He, too, suggests health-care workers as potential (could be others). "All breakthrough no follow-through" is costly. https://www.statnews.com/2021/01/04/stop-debating-first-shot-vs-set-aside-hospitals-should-compare-them/ …pic.twitter.com/XC2Mphm3gj

          4 replies 8 retweets 48 likes
          Show this thread
        8. zeynep tufekci‏Verified account @zeynep 8 Jan 2021

          zeynep tufekci Retweeted Isaac Bogoch

          WHO expert committee says delaying booster up to six weeks (given supply issues) rather than three is okay (based on existing data) and also says will update recommendations for delay as more data becomes available.https://twitter.com/BogochIsaac/status/1347545566679592960 …

          zeynep tufekci added,

          Isaac BogochVerified account @BogochIsaac
          Pfizer #COVID19 vaccine & new WHO recommendations: *You still need 2 doses *You should still try to dose as per schedule But due to supply, "interval between doses may be extended up to 42 days, on the basis of currently available clinical trial data". https://bit.ly/35jENK4 
          5 replies 32 retweets 85 likes
          Show this thread
        9. zeynep tufekci‏Verified account @zeynep 8 Jan 2021

          Details from the WHO expert committee: "Countries experiencing exceptional epidemiological circumstances may consider delaying for a short period the administration of the second dose as a pragmatic approach to maximizing the number of individuals benefiting from a first dose."pic.twitter.com/INAZ6Iy6j5

          4 replies 14 retweets 74 likes
          Show this thread
        10. zeynep tufekci‏Verified account @zeynep 8 Jan 2021

          Biden administration will indeed stop keeping second dose in reserve and front-load the vaccine distribution. (NB: I advocated for a *trial* asap on delayed booster & not keeping second dose in reserve. I also support having these trades-off discussions).https://www.cnn.com/2021/01/08/politics/biden-vaccine-strategy/index.html …

          7 replies 20 retweets 115 likes
          Show this thread
        11. zeynep tufekci‏Verified account @zeynep 22 Jan 2021

          zeynep tufekci Retweeted Michael Nedelman

          So update. CDC says some delay is okay & "if the second dose is administered beyond these intervals, there is no need to restart the series." I will repeat my plea that such modifications need a randomization and data gathering component for more clarity.https://twitter.com/MikeNedelman/status/1352406577664450561 …

          zeynep tufekci added,

          Michael NedelmanVerified account @MikeNedelman
          Amid doubts over Covid vaccine availability, CDC appears to have updated guidance Ppl can wait "up to 6 weeks" for 2nd dose if they can't make recommended interval Vaccines not interchangeable... but if you got Pfizer & it's no longer available, OK to get Moderna—or vice versa
          Show this thread
          7 replies 29 retweets 128 likes
          Show this thread
        12. zeynep tufekci‏Verified account @zeynep 24 Jan 2021

          zeynep tufekci Retweeted Martin Landray

          The man who leads the UK RECOVERY trials which produced incredibly useful information—including drugs that greatly reduce mortality—suggests a randomized trial of delayed dosing. Amazing how “controversies” evolve. 🤷‍♀️(Yes, we obviously should, as per first tweet in this thread.)https://twitter.com/MartinLandray/status/1353272270270181379 …

          zeynep tufekci added,

          Martin Landray @MartinLandray
          Looks like it’s time for a randomised trial of early vs later second dose. If start now, would have data to inform policy in Mar/Apr Might delay be better or worse? We don’t know. A large randomised trial would be very simple & very informative. https://www.theguardian.com/world/2021/jan/23/vaccine-experts-defend-uk-decision-to-delay-second-pfizer-covid-jab?CMP=Share_iOSApp_Other …
          4 replies 15 retweets 113 likes
          Show this thread
        13. zeynep tufekci‏Verified account @zeynep 12 Feb 2021

          Seems Michael Osterholm (of Biden Covid task force) calls for delaying the second dose a few months to increase coverage now. (Because I keep having to clarify: My co-authored piece called for *A TRIAL* exactly so such discussions could have better data). https://www.cidrap.umn.edu/covid-19/podcasts-webinars/episode-42 …pic.twitter.com/f1AkWZjIrv

          10 replies 8 retweets 69 likes
          Show this thread
        14. zeynep tufekci‏Verified account @zeynep 1 Apr 2021

          zeynep tufekci Retweeted Atul Gawande

          Updating this thread started on December 18, 2020 with me and @michaelmina_lab proposing an immediate *trial* for delaying the booster and monitoring the results. We both caught much grief then but if we had started a trial then, we'd know for sure by now.https://twitter.com/Atul_Gawande/status/1377275975050924040 …

          zeynep tufekci added,

          Atul GawandeVerified account @Atul_Gawande
          As cases and hospitalizations rise again, we can't count on behavior alone reversing this course. Therefore, it's time for the Biden admin to delay 2nd vax doses to 12 weeks. Getting as many people as possible a vax dose is now urgent. https://twitter.com/Atul_Gawande/status/1376888536129998850?s=20 …
          Show this thread
          16 replies 27 retweets 179 likes
          Show this thread
        15. End of conversation

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