Not all mRNA vaccines have "brutal cold chain logistics" -- Moderna's is stable for a month at 4°C (vs. e.g. JNJ, stable for 90 days at 4C). Furthermore, at scale, mRNA vaccines are *cheaper* and *faster* to make than adenovirus vectored vaccines. @peterstaley @gregggonsalveshttps://twitter.com/Canadian_JACD/status/1343631239987814402 …
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Replying to @jbkrell @peterstaley
Question is: should a study of one-dose of the current vaccines be initiated?
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Replying to @gregggonsalves @peterstaley
Yes! mRNA-1273 should, of course, be evaluated for one dose, esp. considering the nasal swab data and the immunogenicity data. But, this discussion is missing the (raging burning) forest for a single tree! The real problem is that we are not making enough of mRNA-1273.pic.twitter.com/eeNmPa7gk8
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Replying to @jbkrell @peterstaley
@SaadOmer3@jallepap@michaelmina_lab@k_stephensonMD@zeynep@NateSilver538@Canadian_JACD@mattyglesias1 reply 0 retweets 0 likes -
Replying to @gregggonsalves @peterstaley and
According to
@PrEP4AllNow's (internal) vaccine production tracker, only 500 million doses of mRNA-1273 are gonna be made in 2021. More are going to be made of Pfizer\BioNTech, but that has an actual brutal cold chain (-70C).2 replies 3 retweets 10 likes -
Replying to @jbkrell @gregggonsalves and
So the rest are adenovirus vectored, inactivated whole virus (
) and subunit vaccines. The question is, given the bad results of AZD1222, how confident should we be that other Ad vectored vaccines are going to be better?1 reply 0 retweets 4 likes -
Replying to @jbkrell @gregggonsalves and
There is some reason to think that e.g. JNJ-78436735 will be better than AZD1222, because it use the perfusion stabilized version spike (rather than wt spike), like both successful mRNA vaccines. But we don't know that!
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Replying to @jbkrell @gregggonsalves and
*perfusion conformation stabilized. The whole virus and subunits may also work, but there inherent inability to induce CD8+ T-cell response gives us pause.
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Replying to @jbkrell @gregggonsalves and
tl;dr -- the one vaccine we know works and has a good cold chain properties (Moderna's mRNA-1273), the world is making the least of.
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Replying to @jbkrell @gregggonsalves and
This thread is a very good one. Making more of mRNA-1273 would solve the issues of number of doses much more efficiently than experimenting with dosing regimens
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Indeed, it would be awesome not to have a shortage. We’d still want to know how much/when to prioritize chasing people down for booster. Ideally, this would not be a question at all, but we obviously have a severe last mile problem in the United States. Too slow a rollout.
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