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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. James Krellenstein‏ @jbkrell 28 Dec 2020

      James Krellenstein Retweeted Joseph Delaney, PhD

      Not all mRNA vaccines have "brutal cold chain logistics" -- Moderna's is stable for a month at 4°C (vs. e.g. JNJ, stable for 90 days at 4C). Furthermore, at scale, mRNA vaccines are *cheaper* and *faster* to make than adenovirus vectored vaccines. @peterstaley @gregggonsalveshttps://twitter.com/Canadian_JACD/status/1343631239987814402 …

      James Krellenstein added,

      Joseph Delaney, PhD @Canadian_JACD
      Replying to @k_stephensonMD @michaelmina_lab and 6 others
      The question I have is mRNA vaccines have brutal cold chain logistics and high costs. Are single dose mRNA trials (taking 6 months at best speed) going to trump the ones with better logistics?
      4 replies 7 retweets 18 likes
    2. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @jbkrell @peterstaley

      Question is: should a study of one-dose of the current vaccines be initiated?

      1 reply 0 retweets 2 likes
    3. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @gregggonsalves @peterstaley

      Yes! mRNA-1273 should, of course, be evaluated for one dose, esp. considering the nasal swab data and the immunogenicity data. But, this discussion is missing the (raging burning) forest for a single tree! The real problem is that we are not making enough of mRNA-1273.pic.twitter.com/eeNmPa7gk8

      2 replies 2 retweets 12 likes
    4. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @jbkrell @peterstaley

      @SaadOmer3 @jallepap @michaelmina_lab @k_stephensonMD @zeynep @NateSilver538 @Canadian_JACD @mattyglesias

      1 reply 0 retweets 0 likes
    5. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @gregggonsalves @peterstaley and

      According to @PrEP4AllNow's (internal) vaccine production tracker, only 500 million doses of mRNA-1273 are gonna be made in 2021. More are going to be made of Pfizer\BioNTech, but that has an actual brutal cold chain (-70C).

      2 replies 3 retweets 10 likes
    6. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @jbkrell @gregggonsalves and

      So the rest are adenovirus vectored, inactivated whole virus (🇨🇳) and subunit vaccines. The question is, given the bad results of AZD1222, how confident should we be that other Ad vectored vaccines are going to be better?

      1 reply 0 retweets 4 likes
    7. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @jbkrell @gregggonsalves and

      There is some reason to think that e.g. JNJ-78436735 will be better than AZD1222, because it use the perfusion stabilized version spike (rather than wt spike), like both successful mRNA vaccines. But we don't know that!

      1 reply 0 retweets 5 likes
    8. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @jbkrell @gregggonsalves and

      *perfusion conformation stabilized. The whole virus and subunits may also work, but there inherent inability to induce CD8+ T-cell response gives us pause.

      1 reply 0 retweets 4 likes
    9. James Krellenstein‏ @jbkrell 28 Dec 2020
      Replying to @jbkrell @gregggonsalves and

      tl;dr -- the one vaccine we know works and has a good cold chain properties (Moderna's mRNA-1273), the world is making the least of.

      5 replies 18 retweets 36 likes
      zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @jbkrell @gregggonsalves and

      And how/who is looking at paths for scaling that up?

      2:02 PM - 28 Dec 2020
      0 replies 0 retweets 0 likes

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