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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @gregggonsalves @jallepap and

      The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.

      6 replies 1 retweet 56 likes
    2. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

      3 replies 1 retweet 30 likes
    3. Katy Stephenson, MD, MPH‏ @k_stephensonMD 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      The problem isn’t trial design. Every one of these options has been written up, designed, proposed. The problem is how many efficacy trials can a society support with finite # of investigators, volunteers, cash and morale, all in the face of multitudes of other important studies.

      2 replies 2 retweets 56 likes
    4. Prasad Jallepalli, MD, PhD‏ @jallepap 28 Dec 2020
      Replying to @k_stephensonMD @zeynep and

      In truth, this is the most limiting resource. Ideas are easy, but execution (in this case, of an informative experiment, much less 5 or 10 of them) is the hard(est) problem.

      1 reply 0 retweets 16 likes
    5. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @jallepap @k_stephensonMD and

      And suppose a single dose candidate without the need for a (super) cold chain emerges, less expensive and easier to produce? As @k_stephensonMD suggests the trade-offs are larger here: what do we do with limited time, resources and money? 1/

      1 reply 0 retweets 12 likes
    6. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Important thing here is not to ask is this a good idea, but in the words of one of the smartest people I know (@ADPaltiel), but to ask compared to what? Choices are trade-offs. Have to pull out and look at the entire landscape of vaccine development. End/

      1 reply 1 retweet 23 likes
    7. zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Resources are limited to the degree there is no push for more resources. We live in very very wealthy countries, and if we start “with resources limited” and stop there we don’t get the resources. It’s exactly the reason to push for more.

      2 replies 2 retweets 30 likes
    8. Gummy Bear Messiah‏ @zero132132 28 Dec 2020
      Replying to @zeynep @ElissaBeth and

      If the resource being discussed is people with the necessary skills to handle large scale human trials, what exactly does "getting more" look like?

      1 reply 0 retweets 1 like
    9. Michael Mina‏Verified account @michaelmina_lab 28 Dec 2020
      Replying to @zero132132 @zeynep and

      The resources simply aren’t an issue. If we want to run the trials, we can. It’s an issue of will. In US, decision makers will not benefit from moving to a single dose. They’ll all be vaccinated. So we are witnessing a lack of will and breakdown of global responsibility.

      2 replies 2 retweets 8 likes
    10. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
      Replying to @michaelmina_lab @zero132132 and

      I'm just a little sensitive about 'resources aren't an issue' - as I sit in my office updating ipads for the next vaccine trial, kids at home on holiday, wondering how many more days like this can I give. And I'm not the only one of these 'resources' who feel this way.

      5 replies 3 retweets 37 likes
      zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @k_stephensonMD @michaelmina_lab and

      What would help? More people? How could we get there? We can push for the money, and how could that money be translated into personnel? Also for what it’s worth, country’s like my home country, Turkey, are running trials and have a lot of qualified personnel.

      12:17 PM - 28 Dec 2020
      • 4 Likes
      • Nicest Snog🔎 Elissa Shevinsky Dr Ed Steven Berry
      1 reply 0 retweets 4 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 28 Dec 2020
          Replying to @zeynep @k_stephensonMD and

          There are multiple bottlenecks, and the task is to figure out how to best get through them. Given the history of how this works, it’s no small threat that once we get most privileged ~billion vaccinated, the pressure goes away. So asking for the right things is important.

          1 reply 4 retweets 13 likes
        3. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
          Replying to @zeynep @michaelmina_lab and

          This is a really good point, and I completely agree. The US has prioritized individual-benefit trials. Hopefully @JoeBiden and team will see differently. Your advocacy can only help, and I'm thankful for that. And there are many brilliant physician-scientists abroad. 100% agree.

          1 reply 0 retweets 4 likes
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