Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.
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Replying to @zeynep @gregggonsalves and
The problem isn’t trial design. Every one of these options has been written up, designed, proposed. The problem is how many efficacy trials can a society support with finite # of investigators, volunteers, cash and morale, all in the face of multitudes of other important studies.
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Replying to @k_stephensonMD @zeynep and
In truth, this is the most limiting resource. Ideas are easy, but execution (in this case, of an informative experiment, much less 5 or 10 of them) is the hard(est) problem.
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Replying to @jallepap @k_stephensonMD and
And suppose a single dose candidate without the need for a (super) cold chain emerges, less expensive and easier to produce? As
@k_stephensonMD suggests the trade-offs are larger here: what do we do with limited time, resources and money? 1/1 reply 0 retweets 12 likes -
Replying to @gregggonsalves @jallepap and
Important thing here is not to ask is this a good idea, but in the words of one of the smartest people I know (
@ADPaltiel), but to ask compared to what? Choices are trade-offs. Have to pull out and look at the entire landscape of vaccine development. End/1 reply 1 retweet 23 likes -
Replying to @gregggonsalves @jallepap and
Resources are limited to the degree there is no push for more resources. We live in very very wealthy countries, and if we start “with resources limited” and stop there we don’t get the resources. It’s exactly the reason to push for more.
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Replying to @zeynep @gregggonsalves and
If an idea is baseless or has already been shown to be pointless sure no need to waste more resources on it. But if that’s not yet the case, I don’t see the point of negotiating ourselves down without even asking for trials? Trillions are being spent on all this.
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Replying to @zeynep @gregggonsalves and
Totally agree - we need to keep fighting for the $$$ and investment in science infrastructure, especially for public health-focused studies and not just licensure studies. I only point out that if even $ were available, the staff for the trials are at the breaking point.
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Replying to @k_stephensonMD @zeynep and
We can run trials much more efficiently than we usually do. Particularly with a vaccine now being rolled out. We are talking about a trial of tens of thousands, to potentially improve access and early receipt for billions. We can do these trials if we wanted.
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Replying to @michaelmina_lab @zeynep and
Makes sense. So let’s get granular about the “we.” The NIH is pretty much at max capacity. So how about we turn abroad? That’s where pharma will likely go. And the ethics of placebo there? Seriously asking because the studies have to happen, we know this. But how?
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I think there are multiple countries where we could ethically run a prime vax+placebo/booster trial because it would be better than the current option for the people enrolled, which is no vaccine. We could also ask for volunteers here for booster delay, with monitoring.
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Replying to @zeynep @michaelmina_lab and
FWIW Johnson & Johnson is doing 2 separate efficacy trials right now - 2 doses and 1 dose. Should have read-out for the 1 dose in the next month. This is in no small part to advocacy from Dan Barouch and others 6 months ago. Good Q is why Pfizer and Moderna are not doing this.
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Replying to @k_stephensonMD @zeynep and
If they have data that says it's not worth our time, they should share it. Then OWS and others can make an educated decision about its value. If they don't have that data, then they should answer as to why it's not worth their $$ to test it. (See, I agree on the big issues!)
1 reply 1 retweet 7 likes - Show replies
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