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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

      3 replies 1 retweet 30 likes
    2. Katy Stephenson, MD, MPH‏ @k_stephensonMD 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      The problem isn’t trial design. Every one of these options has been written up, designed, proposed. The problem is how many efficacy trials can a society support with finite # of investigators, volunteers, cash and morale, all in the face of multitudes of other important studies.

      2 replies 2 retweets 56 likes
    3. Prasad Jallepalli, MD, PhD‏ @jallepap 28 Dec 2020
      Replying to @k_stephensonMD @zeynep and

      In truth, this is the most limiting resource. Ideas are easy, but execution (in this case, of an informative experiment, much less 5 or 10 of them) is the hard(est) problem.

      1 reply 0 retweets 16 likes
    4. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @jallepap @k_stephensonMD and

      And suppose a single dose candidate without the need for a (super) cold chain emerges, less expensive and easier to produce? As @k_stephensonMD suggests the trade-offs are larger here: what do we do with limited time, resources and money? 1/

      1 reply 0 retweets 12 likes
    5. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Important thing here is not to ask is this a good idea, but in the words of one of the smartest people I know (@ADPaltiel), but to ask compared to what? Choices are trade-offs. Have to pull out and look at the entire landscape of vaccine development. End/

      1 reply 1 retweet 23 likes
    6. zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Resources are limited to the degree there is no push for more resources. We live in very very wealthy countries, and if we start “with resources limited” and stop there we don’t get the resources. It’s exactly the reason to push for more.

      2 replies 2 retweets 30 likes
    7. zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @zeynep @gregggonsalves and

      If an idea is baseless or has already been shown to be pointless sure no need to waste more resources on it. But if that’s not yet the case, I don’t see the point of negotiating ourselves down without even asking for trials? Trillions are being spent on all this.

      1 reply 0 retweets 16 likes
    8. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Totally agree - we need to keep fighting for the $$$ and investment in science infrastructure, especially for public health-focused studies and not just licensure studies. I only point out that if even $ were available, the staff for the trials are at the breaking point.

      2 replies 0 retweets 14 likes
    9. Michael Mina‏Verified account @michaelmina_lab 28 Dec 2020
      Replying to @k_stephensonMD @zeynep and

      We can run trials much more efficiently than we usually do. Particularly with a vaccine now being rolled out. We are talking about a trial of tens of thousands, to potentially improve access and early receipt for billions. We can do these trials if we wanted.

      2 replies 1 retweet 13 likes
    10. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
      Replying to @michaelmina_lab @zeynep and

      Makes sense. So let’s get granular about the “we.” The NIH is pretty much at max capacity. So how about we turn abroad? That’s where pharma will likely go. And the ethics of placebo there? Seriously asking because the studies have to happen, we know this. But how?

      3 replies 2 retweets 17 likes
      zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @k_stephensonMD @michaelmina_lab and

      I think there are multiple countries where we could ethically run a prime vax+placebo/booster trial because it would be better than the current option for the people enrolled, which is no vaccine. We could also ask for volunteers here for booster delay, with monitoring.

      10:33 AM - 28 Dec 2020
      • 7 Likes
      • santiago tena 🎗🌈🌊 Govind Persad Information Junkie 👨‍💻 Josh You jjmplsmn🗽 Katy Stephenson, MD, MPH Michael Mina
      1 reply 0 retweets 7 likes
        1. New conversation
        2. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
          Replying to @zeynep @michaelmina_lab and

          FWIW Johnson & Johnson is doing 2 separate efficacy trials right now - 2 doses and 1 dose. Should have read-out for the 1 dose in the next month. This is in no small part to advocacy from Dan Barouch and others 6 months ago. Good Q is why Pfizer and Moderna are not doing this.

          2 replies 1 retweet 11 likes
        3. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
          Replying to @k_stephensonMD @zeynep and

          If they have data that says it's not worth our time, they should share it. Then OWS and others can make an educated decision about its value. If they don't have that data, then they should answer as to why it's not worth their $$ to test it. (See, I agree on the big issues!)

          1 reply 1 retweet 7 likes
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