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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Michael Mina‏Verified account @michaelmina_lab 27 Dec 2020
      Replying to @Canadian_JACD @gregggonsalves and

      There are literally billions of people not getting vaccinated at the moment. We do not need an inferiority trial to do this ethically. There are many many ways to do this.

      4 replies 3 retweets 72 likes
    2. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @michaelmina_lab @Canadian_JACD and

      Hey, just one option. Was responding to idea we needed placebo.

      3 replies 0 retweets 10 likes
    3. Prasad Jallepalli, MD, PhD‏ @jallepap 27 Dec 2020
      Replying to @gregggonsalves @michaelmina_lab and

      It’s worth trialing, but let’s be clear about the priors. The scant data we have are consistent with the expectation of a short-lived and non-anamnestic immune response after a first priming dose. It would be great if the SARS-CoV2 spike protein is the exception to this rule.

      10 replies 20 retweets 177 likes
    4. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @jallepap @michaelmina_lab and

      This is #publichealth #epitwitter at its best.

      7 replies 5 retweets 61 likes
    5. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @gregggonsalves @jallepap and

      The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.

      6 replies 1 retweet 56 likes
    6. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

      3 replies 1 retweet 30 likes
    7. Katy Stephenson, MD, MPH‏ @k_stephensonMD 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      The problem isn’t trial design. Every one of these options has been written up, designed, proposed. The problem is how many efficacy trials can a society support with finite # of investigators, volunteers, cash and morale, all in the face of multitudes of other important studies.

      2 replies 2 retweets 56 likes
    8. Prasad Jallepalli, MD, PhD‏ @jallepap 28 Dec 2020
      Replying to @k_stephensonMD @zeynep and

      In truth, this is the most limiting resource. Ideas are easy, but execution (in this case, of an informative experiment, much less 5 or 10 of them) is the hard(est) problem.

      1 reply 0 retweets 16 likes
    9. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @jallepap @k_stephensonMD and

      And suppose a single dose candidate without the need for a (super) cold chain emerges, less expensive and easier to produce? As @k_stephensonMD suggests the trade-offs are larger here: what do we do with limited time, resources and money? 1/

      1 reply 0 retweets 12 likes
    10. Gregg Gonsalves‏Verified account @gregggonsalves 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Important thing here is not to ask is this a good idea, but in the words of one of the smartest people I know (@ADPaltiel), but to ask compared to what? Choices are trade-offs. Have to pull out and look at the entire landscape of vaccine development. End/

      1 reply 1 retweet 23 likes
      zeynep tufekci‏Verified account @zeynep 28 Dec 2020
      Replying to @gregggonsalves @jallepap and

      Resources are limited to the degree there is no push for more resources. We live in very very wealthy countries, and if we start “with resources limited” and stop there we don’t get the resources. It’s exactly the reason to push for more.

      9:43 AM - 28 Dec 2020
      • 2 Retweets
      • 30 Likes
      • Tierney O’Dea 𝕁𝗼𝗻𝗮𝘁𝗵𝗮𝗻 𝗥𝕠𝕤𝕖𝕟𝕓𝕝𝕦𝕞 V. Beat SARS-CoV2-gether Dr. Deborah J. Hankinson Nicest Snog🔎 Ronit A Dancis רונית אביבה Big Pharma Cheats b9n10nt
      2 replies 2 retweets 30 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 28 Dec 2020
          Replying to @zeynep @gregggonsalves and

          If an idea is baseless or has already been shown to be pointless sure no need to waste more resources on it. But if that’s not yet the case, I don’t see the point of negotiating ourselves down without even asking for trials? Trillions are being spent on all this.

          1 reply 0 retweets 16 likes
        3. Katy Stephenson, MD, MPH‏ @k_stephensonMD 28 Dec 2020
          Replying to @zeynep @gregggonsalves and

          Totally agree - we need to keep fighting for the $$$ and investment in science infrastructure, especially for public health-focused studies and not just licensure studies. I only point out that if even $ were available, the staff for the trials are at the breaking point.

          2 replies 0 retweets 14 likes
        4. Show replies
        1. New conversation
        2. Gummy Bear Messiah‏ @zero132132 28 Dec 2020
          Replying to @zeynep @ElissaBeth and

          If the resource being discussed is people with the necessary skills to handle large scale human trials, what exactly does "getting more" look like?

          1 reply 0 retweets 1 like
        3. Michael Mina‏Verified account @michaelmina_lab 28 Dec 2020
          Replying to @zero132132 @zeynep and

          The resources simply aren’t an issue. If we want to run the trials, we can. It’s an issue of will. In US, decision makers will not benefit from moving to a single dose. They’ll all be vaccinated. So we are witnessing a lack of will and breakdown of global responsibility.

          2 replies 2 retweets 8 likes
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