There are literally billions of people not getting vaccinated at the moment. We do not need an inferiority trial to do this ethically. There are many many ways to do this.
-
-
Replying to @michaelmina_lab @Canadian_JACD and
Hey, just one option. Was responding to idea we needed placebo.
3 replies 0 retweets 10 likes -
Replying to @gregggonsalves @michaelmina_lab and
It’s worth trialing, but let’s be clear about the priors. The scant data we have are consistent with the expectation of a short-lived and non-anamnestic immune response after a first priming dose. It would be great if the SARS-CoV2 spike protein is the exception to this rule.
10 replies 20 retweets 177 likes -
Replying to @jallepap @michaelmina_lab and
This is
#publichealth#epitwitter at its best.7 replies 5 retweets 61 likes -
Replying to @gregggonsalves @jallepap and
The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.
6 replies 1 retweet 56 likes -
Replying to @zeynep @gregggonsalves and
Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.
3 replies 1 retweet 30 likes -
Replying to @zeynep @gregggonsalves and
I think Gregg will empathize, given his history. I'm seeing projections of billions remaining unvaccinated in 2021—mostly global south, as it goes. The mRNA vaccines have been spectacular beyond expectation but their trials are also short term. We can/should trial for options.
2 replies 0 retweets 10 likes -
Agree. We need to move quickly on trials of these vaccines and on those in pipeline.
1 reply 0 retweets 8 likes -
Replying to @gregggonsalves @zeynep and
Hi has anyone thought about the cost of publicly advocating for this trial? Could it lead to confusion about the need for a booster? It’s already going to be hard enough to roll out a two-shot regimen.
1 reply 0 retweets 3 likes -
Replying to @MattNoahSmith @gregggonsalves and
The idea is and has been out there. You cannot avoid ideas, especially obvious ones. Suggesting how to do it properly is the way to deal with such potential worries.
2 replies 0 retweets 11 likes
In fact, the question you raise is pretty much all I think about: the new public sphere and how it operates.
-
-
Replying to @zeynep @gregggonsalves and
Ok so my assumption is that advocating for a single shot will invite people to lower their confidence that a second shot is necessary. Can you explain why that assumption is wrong. I’ve picked it up from scientists who are talking another this.
3 replies 0 retweets 3 likes -
Replying to @MattNoahSmith @zeynep and
Well, I think the point is that you do a trial so that you're not reliant on advocacy but have the data to know one way or the other
0 replies 0 retweets 0 likes
End of conversation
New conversation -
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.