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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Joseph Delaney, PhD‏ @Canadian_JACD 27 Dec 2020
      Replying to @gregggonsalves @NateSilver538 @mattyglesias

      I also suspect there is some concern now about a placebo controlled high-risk group as the trial would take months (e.g., 2 months of safety data). Perhaps it needs to be non-inferiority, now. If it is inferior, it might not get an EUA, so a lot of risk is involved.

      3 replies 3 retweets 23 likes
    2. Michael Mina‏Verified account @michaelmina_lab 27 Dec 2020
      Replying to @Canadian_JACD @gregggonsalves and

      There are literally billions of people not getting vaccinated at the moment. We do not need an inferiority trial to do this ethically. There are many many ways to do this.

      4 replies 3 retweets 72 likes
    3. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @michaelmina_lab @Canadian_JACD and

      Hey, just one option. Was responding to idea we needed placebo.

      3 replies 0 retweets 10 likes
    4. Prasad Jallepalli, MD, PhD‏ @jallepap 27 Dec 2020
      Replying to @gregggonsalves @michaelmina_lab and

      It’s worth trialing, but let’s be clear about the priors. The scant data we have are consistent with the expectation of a short-lived and non-anamnestic immune response after a first priming dose. It would be great if the SARS-CoV2 spike protein is the exception to this rule.

      10 replies 20 retweets 177 likes
    5. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @jallepap @michaelmina_lab and

      This is #publichealth #epitwitter at its best.

      7 replies 5 retweets 61 likes
    6. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @gregggonsalves @jallepap and

      The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.

      6 replies 1 retweet 56 likes
    7. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

      3 replies 1 retweet 30 likes
    8. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      I think Gregg will empathize, given his history. I'm seeing projections of billions remaining unvaccinated in 2021—mostly global south, as it goes. The mRNA vaccines have been spectacular beyond expectation but their trials are also short term. We can/should trial for options.

      2 replies 0 retweets 10 likes
    9. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @zeynep @jallepap and

      Agree. We need to move quickly on trials of these vaccines and on those in pipeline.

      1 reply 0 retweets 8 likes
    10. Matthew Noah Smith‏ @MattNoahSmith 27 Dec 2020
      Replying to @gregggonsalves @zeynep and

      Hi has anyone thought about the cost of publicly advocating for this trial? Could it lead to confusion about the need for a booster? It’s already going to be hard enough to roll out a two-shot regimen.

      1 reply 0 retweets 3 likes
      zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @MattNoahSmith @gregggonsalves and

      The idea is and has been out there. You cannot avoid ideas, especially obvious ones. Suggesting how to do it properly is the way to deal with such potential worries.

      2:46 PM - 27 Dec 2020
      • 11 Likes
      • Trusted Source Joe Colucci kai JRP Edwards Dr Isabel Dalhousie ✍🏼No Wireless Modem In Voting Phil Kalina 😐 #GetVaccinated Keen Observer Homiekenobi Acroman39
      2 replies 0 retweets 11 likes
        1. New conversation
        2. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
          Replying to @zeynep @jallepap and

          Agree.

          1 reply 0 retweets 0 likes
        3. Matthew Noah Smith‏ @MattNoahSmith 27 Dec 2020
          Replying to @gregggonsalves @zeynep and

          Ideas do not exist on their own. They have advocates.

          1 reply 0 retweets 0 likes
        4. Show replies
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          In fact, the question you raise is pretty much all I think about: the new public sphere and how it operates.

          1 reply 0 retweets 6 likes
        3. Matthew Noah Smith‏ @MattNoahSmith 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          Ok so my assumption is that advocating for a single shot will invite people to lower their confidence that a second shot is necessary. Can you explain why that assumption is wrong. I’ve picked it up from scientists who are talking another this.

          3 replies 0 retweets 3 likes
        4. Show replies

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