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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Nate Silver‏Verified account @NateSilver538 27 Dec 2020
      Replying to @gregggonsalves @mattyglesias

      As I said in the thread I know scientists *are* talking about it and I've appreciated following the discussions. But it seems like the discussions could be escalated to groups that have regulatory or policymaking authority or some other formal role in the process?

      4 replies 0 retweets 30 likes
    2. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @NateSilver538 @mattyglesias

      We need a clinical trial. That's the first step.

      7 replies 0 retweets 109 likes
    3. Nate Silver‏Verified account @NateSilver538 27 Dec 2020
      Replying to @gregggonsalves @mattyglesias

      I think we're 100% in agreement on that. I know this may be a dumb question but what is the hold-up to commissioning a new trial?

      7 replies 0 retweets 33 likes
    4. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @NateSilver538 @mattyglesias

      Companies have to do them. No one is stopping them. But we're talking about commercial products, so can "make" them do anything, unless...

      9 replies 0 retweets 72 likes
    5. Joseph Delaney, PhD‏ @Canadian_JACD 27 Dec 2020
      Replying to @gregggonsalves @NateSilver538 @mattyglesias

      I also suspect there is some concern now about a placebo controlled high-risk group as the trial would take months (e.g., 2 months of safety data). Perhaps it needs to be non-inferiority, now. If it is inferior, it might not get an EUA, so a lot of risk is involved.

      3 replies 3 retweets 23 likes
    6. Michael Mina‏Verified account @michaelmina_lab 27 Dec 2020
      Replying to @Canadian_JACD @gregggonsalves and

      There are literally billions of people not getting vaccinated at the moment. We do not need an inferiority trial to do this ethically. There are many many ways to do this.

      4 replies 3 retweets 72 likes
    7. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @michaelmina_lab @Canadian_JACD and

      Hey, just one option. Was responding to idea we needed placebo.

      3 replies 0 retweets 10 likes
    8. Prasad Jallepalli, MD, PhD‏ @jallepap 27 Dec 2020
      Replying to @gregggonsalves @michaelmina_lab and

      It’s worth trialing, but let’s be clear about the priors. The scant data we have are consistent with the expectation of a short-lived and non-anamnestic immune response after a first priming dose. It would be great if the SARS-CoV2 spike protein is the exception to this rule.

      10 replies 20 retweets 177 likes
    9. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @jallepap @michaelmina_lab and

      This is #publichealth #epitwitter at its best.

      7 replies 5 retweets 61 likes
    10. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @gregggonsalves @jallepap and

      The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.

      6 replies 1 retweet 56 likes
      zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @zeynep @gregggonsalves and

      Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

      2:32 PM - 27 Dec 2020
      • 1 Retweet
      • 30 Likes
      • Linch Mark Cordell Nicest Snog🔎 b9n10nt Jenny 🐢TurtlesAllTheWayDown🐢 Elissa Shevinsky Dan Sontheimer MD Ammar Piranga
      3 replies 1 retweet 30 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          I think Gregg will empathize, given his history. I'm seeing projections of billions remaining unvaccinated in 2021—mostly global south, as it goes. The mRNA vaccines have been spectacular beyond expectation but their trials are also short term. We can/should trial for options.

          2 replies 0 retweets 10 likes
        3. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
          Replying to @zeynep @jallepap and

          Agree. We need to move quickly on trials of these vaccines and on those in pipeline.

          1 reply 0 retweets 8 likes
        4. Show replies
        1. New conversation
        2. Steve Joffe‏ @SteveJoffe 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          IMO a trial of 1 dose (plus placebo) vs. 2 doses would do the trick. I think we can answer this question without a placebo-only group (and I usually defend the need for placebo controls).

          4 replies 1 retweet 32 likes
        3. davidrlurie‏Verified account @davidrlurie 27 Dec 2020
          Replying to @SteveJoffe @gregggonsalves and

          If there is a clinical demonstration that first shot induces sufficient antibodies to, at minimum, prevent severe cases and does so for months, then deferring second shot could make sense, even if it is ultimately required, no? See this: https://www.sciencemediacentre.org/expert-reaction-to-comments-made-by-tony-blair-suggesting-we-should-consider-using-all-available-vaccine-doses-in-january-as-first-doses-rather-than-keeping-some-back-for-use-as-second-doses/ …

          1 reply 0 retweets 0 likes
        4. Show replies
        1. New conversation
        2. Katy Stephenson, MD, MPH‏ @k_stephensonMD 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          The problem isn’t trial design. Every one of these options has been written up, designed, proposed. The problem is how many efficacy trials can a society support with finite # of investigators, volunteers, cash and morale, all in the face of multitudes of other important studies.

          2 replies 2 retweets 56 likes
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