So, please don't assume that scientists aren't talking about this.
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Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.
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I think Gregg will empathize, given his history. I'm seeing projections of billions remaining unvaccinated in 2021—mostly global south, as it goes. The mRNA vaccines have been spectacular beyond expectation but their trials are also short term. We can/should trial for options.
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All I can say is, this needs to be explored in a trial(s). But here you meet the dilemma, what is the question you want to ask first?
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I think what Michael was getting at is the shortage, sadly, gives us a lot of options for multiple trials. Look at RECOVERY in UK. They took the kitchen sink phase of the clinical response and did trials *through* that phase. We got dexa out of that. US did no such trials.
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Here's one person who had COVID (almost certainly) in March, and again this week. (New variant, perhaps..). So either post-infection immunity declines past 6 months, or existing mutations can defeat that immunity. What does this mean for vaccines?https://twitter.com/bikesandbabies/status/1342865383875895302 …
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Scary stuff. But she wasn’t tested in March and antibodies were negative ~ 4 mos later so unclear if this is 2nd infection or not
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What is the argument against single-dose human challenge trials? A full-blown phase 3 trials could take months to yield a clear result. A human challenge trial could give us an answer in a few weeks.
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Manufacturing standardized batches of coronavirus, and a delivery system, and then titrating it up stepwise to make sure you are getting healthy people sick without overwhelming and killing some of them, is not a thing that can be done hastily.
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I'm in the existing Pfizer trial. They'll be following me for 2 years in part to see how long immunity lasts.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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Did anyone knowledgeable (I am not) worry that a large pop with only 1 dose would be conditions with a higher risk of development of vaccine-resistant variants? (Roughly, with some but less resistance, easier for a mutations to emerge step by step doing better at countering)?
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Great question. Yes amd Questions like these need also be weighed against what it would mean for likelihood of variants to escape if we attained herd immunity, say, 60% faster, and thus had an overall large reduction in opportunities to even escape from It’s a complex question!
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