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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @NateSilver538 @mattyglesias

      So, please don't assume that scientists aren't talking about this.

      5 replies 1 retweet 243 likes
    2. Nate Silver‏Verified account @NateSilver538 27 Dec 2020
      Replying to @gregggonsalves @mattyglesias

      As I said in the thread I know scientists *are* talking about it and I've appreciated following the discussions. But it seems like the discussions could be escalated to groups that have regulatory or policymaking authority or some other formal role in the process?

      4 replies 0 retweets 30 likes
    3. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @NateSilver538 @mattyglesias

      We need a clinical trial. That's the first step.

      7 replies 0 retweets 109 likes
    4. Nate Silver‏Verified account @NateSilver538 27 Dec 2020
      Replying to @gregggonsalves @mattyglesias

      I think we're 100% in agreement on that. I know this may be a dumb question but what is the hold-up to commissioning a new trial?

      7 replies 0 retweets 33 likes
    5. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @NateSilver538 @mattyglesias

      Companies have to do them. No one is stopping them. But we're talking about commercial products, so can "make" them do anything, unless...

      9 replies 0 retweets 72 likes
    6. Joseph Delaney, PhD‏ @Canadian_JACD 27 Dec 2020
      Replying to @gregggonsalves @NateSilver538 @mattyglesias

      I also suspect there is some concern now about a placebo controlled high-risk group as the trial would take months (e.g., 2 months of safety data). Perhaps it needs to be non-inferiority, now. If it is inferior, it might not get an EUA, so a lot of risk is involved.

      3 replies 3 retweets 23 likes
    7. Michael Mina‏Verified account @michaelmina_lab 27 Dec 2020
      Replying to @Canadian_JACD @gregggonsalves and

      There are literally billions of people not getting vaccinated at the moment. We do not need an inferiority trial to do this ethically. There are many many ways to do this.

      4 replies 3 retweets 72 likes
    8. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @michaelmina_lab @Canadian_JACD and

      Hey, just one option. Was responding to idea we needed placebo.

      3 replies 0 retweets 10 likes
    9. Prasad Jallepalli, MD, PhD‏ @jallepap 27 Dec 2020
      Replying to @gregggonsalves @michaelmina_lab and

      It’s worth trialing, but let’s be clear about the priors. The scant data we have are consistent with the expectation of a short-lived and non-anamnestic immune response after a first priming dose. It would be great if the SARS-CoV2 spike protein is the exception to this rule.

      10 replies 20 retweets 177 likes
    10. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
      Replying to @jallepap @michaelmina_lab and

      This is #publichealth #epitwitter at its best.

      7 replies 5 retweets 61 likes
      zeynep tufekci‏Verified account @zeynep 27 Dec 2020
      Replying to @gregggonsalves @jallepap and

      The durability of the immunity is the biggest concern we heard—also even with a booster. When is the next booster? In addition, one option is spacing the booster a little farther—especially for younger cohorts and/or people with prior infections: aka front-loading the supply.

      2:31 PM - 27 Dec 2020
      • 1 Retweet
      • 56 Likes
      • Linch CJ Alexander Shelley Bertram marypg keating aka Mary-the-Cat Nicest Snog🔎 Elsa B. Kania RichardT Dan Sontheimer MD Gabriela Cuello
      6 replies 1 retweet 56 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          Another advantage to an immediate trial is having a better sense of the scale/scope downsides. Some people are going to miss the booster, and require allocation of (limited) resources to track down. So who and when? A trial would help shed light on that.

          3 replies 1 retweet 30 likes
        3. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          I think Gregg will empathize, given his history. I'm seeing projections of billions remaining unvaccinated in 2021—mostly global south, as it goes. The mRNA vaccines have been spectacular beyond expectation but their trials are also short term. We can/should trial for options.

          2 replies 0 retweets 10 likes
        4. Show replies
        1. New conversation
        2. Gregg Gonsalves‏Verified account @gregggonsalves 27 Dec 2020
          Replying to @zeynep @jallepap and

          All I can say is, this needs to be explored in a trial(s). But here you meet the dilemma, what is the question you want to ask first?

          1 reply 0 retweets 8 likes
        3. zeynep tufekci‏Verified account @zeynep 27 Dec 2020
          Replying to @gregggonsalves @jallepap and

          I think what Michael was getting at is the shortage, sadly, gives us a lot of options for multiple trials. Look at RECOVERY in UK. They took the kitchen sink phase of the clinical response and did trials *through* that phase. We got dexa out of that. US did no such trials.

          2 replies 0 retweets 11 likes
        4. Show replies
        1. New conversation
        2. miroirdufou‏ @miroirdufou 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          miroirdufou Retweeted Ruth-Anna

          Here's one person who had COVID (almost certainly) in March, and again this week. (New variant, perhaps..). So either post-infection immunity declines past 6 months, or existing mutations can defeat that immunity. What does this mean for vaccines?https://twitter.com/bikesandbabies/status/1342865383875895302 …

          miroirdufou added,

          Ruth-Anna @bikesandbabies
          On the second day of Christmas, 2020 gave to me, my second dose of covid pic.twitter.com/D2HoRabjTM
          Show this thread
          1 reply 0 retweets 0 likes
        3. KJ, PA-C‏ @KTJanePA 27 Dec 2020
          Replying to @miroirdufou @zeynep and

          Scary stuff. But she wasn’t tested in March and antibodies were negative ~ 4 mos later so unclear if this is 2nd infection or not

          0 replies 0 retweets 0 likes
        4. End of conversation
        1. New conversation
        2. Joe Rice‏ @joe_rice_ 27 Dec 2020
          Replying to @zeynep @gregggonsalves and

          What is the argument against single-dose human challenge trials? A full-blown phase 3 trials could take months to yield a clear result. A human challenge trial could give us an answer in a few weeks.

          1 reply 0 retweets 0 likes
        3. Piranga‏ @RRcandid 27 Dec 2020
          Replying to @joe_rice_ @zeynep and

          Manufacturing standardized batches of coronavirus, and a delivery system, and then titrating it up stepwise to make sure you are getting healthy people sick without overwhelming and killing some of them, is not a thing that can be done hastily.

          0 replies 0 retweets 1 like
        4. End of conversation
        1. Griselda Gimpel‏ @GriseldaGimpel 28 Dec 2020
          Replying to @zeynep @gregggonsalves and

          I'm in the existing Pfizer trial. They'll be following me for 2 years in part to see how long immunity lasts.

          0 replies 0 retweets 1 like
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        1. New conversation
        2. Midge Krienes‏ @MKrienes 28 Dec 2020
          Replying to @zeynep @gregggonsalves and

          Did anyone knowledgeable (I am not) worry that a large pop with only 1 dose would be conditions with a higher risk of development of vaccine-resistant variants? (Roughly, with some but less resistance, easier for a mutations to emerge step by step doing better at countering)?

          1 reply 0 retweets 1 like
        3. Michael Mina‏Verified account @michaelmina_lab 28 Dec 2020
          Replying to @MKrienes @zeynep and

          Great question. Yes amd Questions like these need also be weighed against what it would mean for likelihood of variants to escape if we attained herd immunity, say, 60% faster, and thus had an overall large reduction in opportunities to even escape from It’s a complex question!

          2 replies 0 retweets 3 likes
        4. Show replies

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