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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @EricTopol

      This logic of epistasis and "two-step" changes has a rich history in pop gen. The basic idea is that populations will exhaust all the easy "one-step" changes quickly and so pace of evolution will be partly determined by rarer epistatic combinations. This is mostly theory however.

      1 reply 8 retweets 70 likes
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    4. zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @K_G_Andersen @trvrb and

      Practically speaking, doesn’t all this mean speed of vaccine rollout—globally—is of great importance?

      1 reply 4 retweets 30 likes
    5. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @zeynep @K_G_Andersen and

      Yes. If we're worried about this and further mutations the best thing we can do is to vaccinate as widely and as quickly as possible, (while mitigating spread in the interim).

      3 replies 26 retweets 88 likes
    6. zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @trvrb @K_G_Andersen and

      Yeah that’s what I was inferring from the details—regardless of where we eventually land, data-wise, for this one in particular. I think that very practical, and frankly urgent, implication is missing from the mutant-ninja-virus🚨coverage. (Which means I have my charge!)

      1 reply 0 retweets 18 likes
    7. Jessica Pickett‏ @pickettjessica 22 Dec 2020
      Replying to @zeynep @trvrb and

      Agreed. Major implications for the funding, procurement priorities & allocation mechanisms for the COVAX Facility, as well as further research & manufacturing investments by CEPI .

      1 reply 0 retweets 1 like
    8. Jessica Pickett‏ @pickettjessica 22 Dec 2020
      Replying to @pickettjessica @zeynep and

      Moreover, the likely need for regular formulation updates will be an additional unexpected hurdle for licensing agreements & tech transfer to local manufacturers, not to mention national regulatory capacity.

      1 reply 0 retweets 1 like
    9. Aaron Ruby‏ @aruby_ 22 Dec 2020
      Replying to @pickettjessica @zeynep and

      MRNA platforms have a clear advantage for fast vaccine updates (6 weeks according to Ugur Sahin!) Once we have a correlate of protection from the first trials, hopefully the regulatory burden for updates will ease, like for flu shot updates.

      1 reply 0 retweets 2 likes
    10. Jessica Pickett‏ @pickettjessica 22 Dec 2020
      Replying to @aruby_ @zeynep and

      I do not think this will be nearly as easy for manufacturers in India, let alone Indonesia of Uzbekistan (both of which plan to manufacture Chinese vaccines in exchange for clinical trials).

      1 reply 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @pickettjessica @aruby_ and

      Yeah

      12:36 PM - 22 Dec 2020
      • 2 Likes
      • Jessica Pickett Deirdre Connolly¹
      1 reply 0 retweets 2 likes
        1. New conversation
        2. Aaron Ruby‏ @aruby_ 22 Dec 2020
          Replying to @zeynep @pickettjessica and

          There's a good chance that none of the adenovirus vectors will be reusable due to viral vector immunity. No idea how long it would take to update seed virus for inactivated virus vaccine. Subunit RBD protein from yeast might be the winner for most of the world.

          1 reply 0 retweets 2 likes
        3. VKJudit‏ @VKJudit 22 Dec 2020
          Replying to @aruby_ @zeynep and

          Which would be which of the vaccines already in development?

          1 reply 0 retweets 0 likes
        4. Show replies

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