This logic of epistasis and "two-step" changes has a rich history in pop gen. The basic idea is that populations will exhaust all the easy "one-step" changes quickly and so pace of evolution will be partly determined by rarer epistatic combinations. This is mostly theory however.
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There's a good chance that none of the adenovirus vectors will be reusable due to viral vector immunity. No idea how long it would take to update seed virus for inactivated virus vaccine. Subunit RBD protein from yeast might be the winner for most of the world.
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Which would be which of the vaccines already in development?
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coverage. (Which means I have my charge!)