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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Eric Topol‏Verified account @EricTopol 22 Dec 2020
      Replying to @trvrb

      Makes sense. Thanks, Trevor. And for another excellent thread

      1 reply 0 retweets 40 likes
    2. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @EricTopol

      This logic of epistasis and "two-step" changes has a rich history in pop gen. The basic idea is that populations will exhaust all the easy "one-step" changes quickly and so pace of evolution will be partly determined by rarer epistatic combinations. This is mostly theory however.

      1 reply 8 retweets 70 likes
    3. This Tweet is unavailable.
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    5. zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @K_G_Andersen @trvrb and

      Practically speaking, doesn’t all this mean speed of vaccine rollout—globally—is of great importance?

      1 reply 4 retweets 30 likes
    6. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @zeynep @K_G_Andersen and

      Yes. If we're worried about this and further mutations the best thing we can do is to vaccinate as widely and as quickly as possible, (while mitigating spread in the interim).

      3 replies 26 retweets 88 likes
    7. This Tweet is unavailable.
    8. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @K_G_Andersen @zeynep and

      I think we're talking different timeframes. Most countries in the world weren't able to achieve suppression through NPIs. The most robust strategy for suppression will be widespread vaccine coverage. This will stop continual circulation and the opportunity for variants to arise.

      2 replies 0 retweets 27 likes
    9. zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @trvrb @K_G_Andersen and

      Yes, I’m not asking about the next month—and I hear what you are all saying about how much remains unknown about this strain—but the implication of some of the plans I have seen that assume billions left unvaccinated until 2022.

      3 replies 0 retweets 13 likes
    10. David States‏ @statesdj 22 Dec 2020
      Replying to @zeynep @trvrb and

      If SARS-CoV-2 behaves as does 229E, and there’s no reason to expect it won’t, we should anticipate the need for periodic booster vaccines to cover newly emerging variants every few yearshttps://www.biorxiv.org/content/10.1101/2020.12.17.423313v1 …

      1 reply 2 retweets 4 likes
      zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @statesdj @trvrb and

      I think there’s a real risk funding & sense of urgency will dry up after a (very welcome) plummeting of severe cases. I’m genuinely asking a question here though. What is the tail risk we should understand about the slow roll out? What can we do? (Or is it not that big a worry?)

      11:57 AM - 22 Dec 2020
      • 6 Likes
      • Jordan Fish 🐡 Deirdre Connolly¹ Danielle M. Wenner David States logimech
      1 reply 0 retweets 6 likes
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        2. David States‏ @statesdj 22 Dec 2020
          Replying to @K_G_Andersen @zeynep and

          👆Obviously there will be persistent risk of reintroduction from unvaccinated areas. Regions with less developed economies tend to have much younger populations so they tend to have less severe disease which will help

          1 reply 0 retweets 2 likes
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        2. Jessica Pickett‏ @pickettjessica 22 Dec 2020
          Replying to @zeynep @statesdj and

          From where I sit (global health economist specializing in LMIC vaccine markets), the absolute worst - but unlikely! - case is if by the time 1st gen vaccines are rolled out they already have diminished RBD neutralization but enhanced infectivity from NTD antibodies.

          1 reply 0 retweets 6 likes
        3. Jessica Pickett‏ @pickettjessica 22 Dec 2020
          Replying to @pickettjessica @zeynep and

          Or any other mechanism by which an obsolete formulation is worse than none. Aside from direct harm, that would also further erode public confidence in vaccines more generally.

          1 reply 0 retweets 2 likes
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