Makes sense. Thanks, Trevor. And for another excellent thread
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Obviously there will be persistent risk of reintroduction from unvaccinated areas. Regions with less developed economies tend to have much younger populations so they tend to have less severe disease which will help - Show replies
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From where I sit (global health economist specializing in LMIC vaccine markets), the absolute worst - but unlikely! - case is if by the time 1st gen vaccines are rolled out they already have diminished RBD neutralization but enhanced infectivity from NTD antibodies.
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Or any other mechanism by which an obsolete formulation is worse than none. Aside from direct harm, that would also further erode public confidence in vaccines more generally.
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