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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Trevor Bedford‏Verified account @trvrb 22 Dec 2020

      Trevor Bedford Retweeted Trevor Bedford

      Following up on general thoughts on antigenic drift of #COVID19 from this weekend, I wanted to discuss what we know about the new variant of SARS-CoV-2 thats emerged in the UK. 1/17https://twitter.com/trvrb/status/1340409968818671616 …

      Trevor Bedford added,

      Trevor BedfordVerified account @trvrb
      With #COVID19 vaccine efficacy of ~95%, I'm looking forward to vaccine distribution in 2021 bringing the pandemic under control. However, I'm concerned that we'll see antigenic drift of SARS-CoV-2 and may need to update the strain used in the vaccine with some regularity. 1/18
      Show this thread
      47 replies 829 retweets 1,803 likes
      Show this thread
    2. Eric Topol‏Verified account @EricTopol 22 Dec 2020
      Replying to @trvrb

      I get your point about epistasis of these key variants in B.1.1.7. Do you think the N501Y alone could account for the heightened transmission?

      6 replies 8 retweets 49 likes
    3. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @EricTopol

      The main reason I'd think it's not N501Y alone is that this AA change is due to a single nuc change A23063T. This mutation should be repeatedly across global infections. I'd think you'd need some epistatic effect to enable this mutation. Otherwise it should have spread earlier.

      2 replies 19 retweets 114 likes
    4. Eric Topol‏Verified account @EricTopol 22 Dec 2020
      Replying to @trvrb

      Makes sense. Thanks, Trevor. And for another excellent thread

      1 reply 0 retweets 40 likes
    5. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
      Replying to @EricTopol

      This logic of epistasis and "two-step" changes has a rich history in pop gen. The basic idea is that populations will exhaust all the easy "one-step" changes quickly and so pace of evolution will be partly determined by rarer epistatic combinations. This is mostly theory however.

      1 reply 8 retweets 70 likes
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      zeynep tufekci‏Verified account @zeynep 22 Dec 2020
      Replying to @K_G_Andersen @trvrb and

      Practically speaking, doesn’t all this mean speed of vaccine rollout—globally—is of great importance?

      11:24 AM - 22 Dec 2020
      • 4 Retweets
      • 30 Likes
      • Jasmin vom Walde Ryan Hisner Johnny Rhee🔴 ☀️🦅Daya G.✨🐢 Luke Groesbeck Cristen Willer, PhD D BLACK LIVES MATTER Schmitt MaximusDerrick Tammara Webber
      1 reply 4 retweets 30 likes
        1. New conversation
        2. Trevor Bedford‏Verified account @trvrb 22 Dec 2020
          Replying to @zeynep @K_G_Andersen and

          Yes. If we're worried about this and further mutations the best thing we can do is to vaccinate as widely and as quickly as possible, (while mitigating spread in the interim).

          3 replies 26 retweets 88 likes
        3. Sean Tompkins MD, PhD‏ @sctomp 22 Dec 2020
          Replying to @trvrb @zeynep and

          So then vaccine priority should be based on likelihood of being a vector, not mortality, no?

          1 reply 0 retweets 1 like
        4. Show replies

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