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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Michael Mina‏Verified account @michaelmina_lab 18 Dec 2020
      Replying to @K_G_Andersen @TAGHIVscience and

      Weak yes - which is why we need the study. However, the data we DO have shows a 92% efficacy among people without a second dose. I don't see how this is so weak we should not seriously consider it. 2/983 vs 28/1059. Durability unknown - some ppl go out to 108 days.

      1 reply 1 retweet 7 likes
    2. This Tweet is unavailable.
    3. Richard M. Carpiano, PhD, MPH‏ @RMCarpiano 18 Dec 2020
      Replying to @K_G_Andersen @michaelmina_lab and

      Key word there: "scientific debate." Not "public newspaper debate."

      2 replies 0 retweets 4 likes
    4. Nsikan Akpan, PhD‏Verified account @MoNscience 18 Dec 2020
      Replying to @RMCarpiano @K_G_Andersen and

      A possible flaw with the single-dose idea: What would the comparison group be for these trials? If it's unethical to deny placebo-takers the vaccine, wouldn't it also be unethical to deny two doses to a single-dose taker if the latter provides better protection? 1/2

      1 reply 0 retweets 8 likes
    5. Nsikan Akpan, PhD‏Verified account @MoNscience 18 Dec 2020
      Replying to @MoNscience @RMCarpiano and

      I ask that because the Moderna trials only reported significant neutralizing antibodies/T cell responses after the second dose. 2/2pic.twitter.com/HK9iZtxKKO

      0 replies 0 retweets 11 likes
    6. This Tweet is unavailable.
    7. zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @K_G_Andersen @MoNscience and

      One option would be to offer vax+vax/placebo trial to groups not getting any vaccine right now. Given the shortage, there is no way avoiding denying something to large numbers of people; and if we don't try but later find single-dose holds up, we've denied maybe a billion people.

      1 reply 0 retweets 5 likes
    8. zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @zeynep @K_G_Andersen and

      Plus, there will be people who miss the second dose anyway, and there will need to be an effort to track them down. Just saying "please don't miss your dose" won't work; these things need resources. With a trial, we can make a smarter decision on that.

      1 reply 0 retweets 1 like
    9. Nsikan Akpan, PhD‏Verified account @MoNscience 19 Dec 2020
      Replying to @zeynep @K_G_Andersen and

      Hmm, a retro trial with people who miss their second dose would be an interesting way to do it. Randomization and measuring immune responses would be tricky....

      1 reply 0 retweets 1 like
    10. Nsikan Akpan, PhD‏Verified account @MoNscience 19 Dec 2020
      Replying to @MoNscience @zeynep and

      I still feel like the immunology in the Moderna trial is telling us that the single dose may not work. Also plenty of childhood vaccine schedules require 2 doses w/o creating many issues. But I get where you’re coming from and it’s interesting pitch.

      1 reply 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @MoNscience @K_G_Andersen and

      We have two natural, unfortunate conditions, that mean people are going to go unvaccinated: shortages plus people missing the second dose. We can mobilize both to try to get an answer especially since missing second dose going to happen anyway. Also asymmetric info from each.

      10:10 AM - 19 Dec 2020
      • 1 Like
      • Matthew Kleinhans
      1 reply 0 retweets 1 like
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        2. zeynep tufekci‏Verified account @zeynep 19 Dec 2020
          Replying to @zeynep @MoNscience and

          The non-random arm—missing dose in the real world—can give signal to stop randomized trial while not being good enough to green-light. (Part of my conceptual model here is how UK/NHS turned the kitchen sink clinical phase into randomized trials and we got dexa out of that).

          1 reply 0 retweets 0 likes
        3. Nsikan Akpan, PhD‏Verified account @MoNscience 19 Dec 2020
          Replying to @zeynep @K_G_Andersen and

          Yep, all good points. But the data in both trials say that 1 dose doesn’t produce a potent response. So the prudent move would be to keep using 2 doses until a trial shows otherwise? If the rollout switched to 1 dose now and it didn’t work, then we’ve wasted the early supply?pic.twitter.com/5wAdSjbDGB

          2 replies 0 retweets 1 like
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