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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 18 Dec 2020
      Replying to @Laurel_Bristow @EricTopol @michaelmina_lab

      Absolutely agree it should be voluntary. However I did hear from many HCW who said they would volunteer. This should clearly be an adaptive trial, with frequent monitoring. We should be able to pick up signals quickly. It’s a question of proper attention and resource allocation.

      2 replies 1 retweet 5 likes
    2. Laurel Bristow, MSc‏ @Laurel_Bristow 18 Dec 2020
      Replying to @zeynep @EricTopol @michaelmina_lab

      Of course. Thx. Also curious why HCW were proposed to start. Is seems the argument is they are no longer at increased risk (which I find debatable) & if that’s the case why not also offer it to low risk people who wouldn’t get vaccine for a while otherwise, If risk is similar?

      1 reply 0 retweets 0 likes
    3. zeynep tufekci‏Verified account @zeynep 18 Dec 2020
      Replying to @Laurel_Bristow @EricTopol @michaelmina_lab

      I think the latter is a very good option as well!

      1 reply 0 retweets 2 likes
    4. Whitney R. Robinson‏ @WhitneyEpi 19 Dec 2020
      Replying to @zeynep @EricTopol @michaelmina_lab

      I’m also skeptical of the suggestion of HCWs for RCT. The same factors that make them low risk (good infection control in most health care facilities) would make the trial take longer to deliver results. If the goal is fast results, this doesn’t seem like the right population.

      1 reply 0 retweets 3 likes
    5. zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @WhitneyEpi @EricTopol @michaelmina_lab

      Good points. That may argue for offering vax+vax/placebo to a population who’d get no vaccine at this point. Also following up systematically with people who sadly will miss anyway—as happens so much. Bonus, we could vaccinate them after finding them.

      1 reply 0 retweets 2 likes
    6. Whitney R. Robinson‏ @WhitneyEpi 19 Dec 2020
      Replying to @zeynep @EricTopol @michaelmina_lab

      Analyzing those who miss their second dose after usual attempts to contact them (although by definition, this group may be hard to contact for a follow up study) is where observational epidemiology could shine. @UNCpublichealth has a great pharmacoepi group: I’ll ask if plans

      3 replies 0 retweets 5 likes
    7. Whitney R. Robinson‏ @WhitneyEpi 19 Dec 2020
      Replying to @WhitneyEpi @zeynep and

      Have you heard medical ethicists’ take on 1-dose trials among high-exposure people otherwise low on vaccine list, maybe young low-wage essential workers...? I see the benefits but, bc exposure risk is SO patterned by SES & race in US, I’d want lots of ethical analysis in planning

      1 reply 0 retweets 3 likes
    8. zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @WhitneyEpi @EricTopol and

      I’ve heard varying input. If the group was already not getting vaccines now, vax+vax/placebo seems invariably better to me but needs careful planning for sure.

      1 reply 0 retweets 1 like
    9. Whitney R. Robinson‏ @WhitneyEpi 19 Dec 2020
      Replying to @zeynep @EricTopol and

      Keys that come to mind: early community involvement in trial design re: trial stopping point, compensation, & when participants could get second dose...

      1 reply 0 retweets 0 likes
    10. Whitney R. Robinson‏ @WhitneyEpi 19 Dec 2020
      Replying to @WhitneyEpi @zeynep and

      For instance, maybe people you’re trying to recruit prefer cash for compensation but maybe they want something else: a year of free high-health insurance w no deductible or co-pays, guaranteed 2-dose vaccination for up to two relatives by a certain date...

      2 replies 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 19 Dec 2020
      Replying to @WhitneyEpi @EricTopol and

      Adaptive trial! We should be ready to move to stop quickly. The shortage is terrible and the upside is important but we should design with the downside in mind.

      9:33 AM - 19 Dec 2020
      • 3 Likes
      • Alan Jones Amy Cho, MD MBA Whitney R. Robinson
      0 replies 0 retweets 3 likes

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