That is a fundamentally different proposal. It is irresponsible to discuss these complexities in an NYT op Ed piece. The US has failed because of a cacophony of public health voices that have confused the public. Every self proclaimed vaccine/PH expert wants to voice his opinion
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Replying to @ykramerezha @zeynep
I think that that's a very reductive perspective regarding the failure of the US response. I would also add that the authors of this piece are not "self-proclaimed" experts, and multiple other experts also want to see data from a single-dose regimen.
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Replying to @ENirenberg @zeynep
I respect Zeynep but she calls herself an amateur epidemiologist. Dr. Mina confuses marketing with epidemiology & a test with a public health strategy. He stated he can end the pandemic in 3 weeks without TETRIS but with rapid testing. He has been called out by top pandemicists
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Replying to @ykramerezha @zeynep
That is irrelevant to the salient point; they are calling for an additional clinical trial of a single-dose regimen in parallel to the current plans that everyone receive a two-dose series. What, specifically, is incorrect about this?
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If we could do one dose instead of two - the vaccine would be less reactogenic - you wouldn't need to rely nearly as much on patient compliance (returning for a second dose) - if efficacy were sufficient, you could immunize twice as many people with greater public health gains
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Similar questions, and associated research, led to rational, well-supported changes in Gardasil dosing recommendations. After the research was done.
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The authors should have directed their concerns to the vaccine experts and decision makers at BioNTech/Pfizer either directly or through Science/Nature/NEJM. Theirs is a very obvious point rather than an insight. This is a science discussion rather than science communication
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I take your point.
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Their point may well prove helpful. But now hundreds if not thousands will skip the second dose. Many doctors may give one shot only to help their patients. This is guaranteed to cause confusion.
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I think time will bear out the extent that this is true. I can't imagine physicians administering the vaccine to their patients will elect to forgo a second dose on the basis of this op ed.
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I don’t see it happening. If anything, giving the broader info environment where politically powerful people are proposing this without a trial, I would guess this message would be a useful counterbalance.
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