I agree with Dr. @EricTopol. While we should prioritize looking at a single dose regimen as this piece suggests, I worry that the take-home message is that it's okay to skip the second dose or get a booster many months later. We don't know that.https://twitter.com/EricTopol/status/1339957304247033856 …
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Even simply using the current doses to give initial shot to twice as many people and then taking risk there is some delay in deliveries for 2nd shot should be considered, especially as the trial allowed up to a 3 week delay in the booster (6 weeks total).
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It is important to note that the situation we are in - a limited amount available of a surprisingly effective vaccine at the peak point in the outbreak - is a corner case. This is the time to at least CONSIDER alternatives to save lives in the next couple of weeks.
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Clarity abt RCT a moot pt. Again, doesn't justify a NYT op-ed vs. sci journal commentary for expert discussion you say you seek. Implies a "well the horse already left the barn" rationale. If powerful politicians pushing misinfo a concern, then addressing that shld've been focus.
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There seems to be broad agreement—here at least—that a trial is warranted and a disagreement on: if this should be a public discussion and venue. On the first I don’t think we have a choice. We haven’t since the beginning. That’s been an ongoing contention of mine. +
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