Advocating the potential for a single dose of #SARSCoV2 vaccines @zeynep @michaelmina_lab https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html?action=click&module=Opinion&pgtype=Homepage …
The points for studying this are good but the public message to many for skipping the 2nd dose is troubling when we don't really know what protection that provides
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That said, some people are going to miss that second dose (there were many in the trials) and we should make an effort to find them and maybe even swab them right before jabbing them, as Moderna did in the trials.
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This will be a delicate dance. Will the more measured messages win?
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By definition, a quick trial would not tell us about the durability of protection.
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Sure, but by your logic, why then push your pts in NYTimes op-ed vs. commentary in an expert sci community forum (JAMA)? You express hope ppl don't skip 2nd dose but publishing what is conjecture at this pt to public audience risks fueling very thing what you hope people don't do
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The words "quick" and trial do not go together for something like this. Have you even attempted a power analysis?
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