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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 16 Dec 2020

      Geeky question, is there an explanation for why the Moderna vaccine is stable longer than the Pfizer one in terms of cold storage requirements since they're both mRNA? Or is it just that Moderna tested for longer storage times and Pfizer didn't? Links to long papers welcome!

      30 replies 42 retweets 338 likes
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      zeynep tufekci‏Verified account @zeynep 16 Dec 2020

      zeynep tufekci Retweeted Justin

      Difference may be the proprietary method/formula Moderna has for its lipid nanoparticles. I don't know the answer but if it's possible to license/share/apply this technology to the Pfizer vaccine, it could make a huge difference to who will get vaccinated.https://twitter.com/Trumpery45/status/1339336789270568960 …

      zeynep tufekci added,

      Justin @Trumpery45
      Replying to @zeynep
      some hints are here https://www.nationalgeographic.com/science/2020/11/moderna-edges-pfizer-coronavirus-efficacy-and-refrigeration/ … pic.twitter.com/jsYsokgVV8
      2:35 PM - 16 Dec 2020
      • 17 Retweets
      • 129 Likes
      • wombot 👀 Nora Rawn Pierre Igot EyeForTruth Nico Vallone Natanael, tech custodial engineer Rasmus Fonnesbæk Hatta erika at rest remains at rest
      6 replies 17 retweets 129 likes
        1. zeynep tufekci‏Verified account @zeynep 16 Dec 2020

          Pfizer distribution is going to be much harder and more costly because of its (relatively extreme) refrigeration requirements and shorter shelf-life. This hinders immunization outside hospitals in the US, and makes it much harder in poorer countries. Just looking to learn why/if.

          10 replies 7 retweets 93 likes
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        2. JDB‏ @JDB0711 16 Dec 2020
          Replying to @zeynep

          Pfizer would have to conduct new phase 3 trials if they radically changed the formulation like that, so not going to happen even if Moderna was willing to license the technology...

          1 reply 0 retweets 4 likes
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        1. Jenny Teehan, MD‏ @MADDMAAM 16 Dec 2020
          Replying to @zeynep

          👆🏼

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        1. LarissaManwaring (Man·​er·ing)‏ @LManwaring 16 Dec 2020
          Replying to @zeynep

          they can't change the vaccine.

          0 replies 0 retweets 1 like
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        1. ForeignOrchid‏ @foreignorchid 16 Dec 2020
          Replying to @zeynep

          Even of shared, it'd have to be proven. That is another 6+ months. It'd be similar to lots of drug expiration dates. Aspirin is 5 years. Not because year 6 it changes but because year 6+ were never tested and proven to the FDA.

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        2. Timothy Lune‏ @timlune 16 Dec 2020
          Replying to @russss @zeynep

          But the CureVac vaccine has similar refrigeration requirements as Moderna's, therefore Acuitas nanoparticles don't explain the difference. https://www.curevac.com/en/covid-19/ pic.twitter.com/m8HFkH2Y4X

          0 replies 0 retweets 0 likes
        3. End of conversation
        1. Dr. Dickweed‏ @Dr__Dickweed 16 Dec 2020
          Replying to @zeynep

          I love lipid nanoparticles

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