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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 16 Dec 2020

      Geeky question, is there an explanation for why the Moderna vaccine is stable longer than the Pfizer one in terms of cold storage requirements since they're both mRNA? Or is it just that Moderna tested for longer storage times and Pfizer didn't? Links to long papers welcome!

      30 replies 42 retweets 338 likes
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    2. Drew Conway‏Verified account @drewconway 16 Dec 2020
      Replying to @zeynep

      As I understand it, Moderna developed a new lipid nanoparticle that was much stronger than the previous state of the art https://scholar.google.com/scholar?q=moderna+lipid+nanoparticles+covid&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3DGuS3LLrmT7MJ …

      1 reply 1 retweet 28 likes
      zeynep tufekci‏Verified account @zeynep 16 Dec 2020
      Replying to @drewconway

      Right, I'm wondering why/if there isn't a way to license or apply this to Pfizer as well? The difference isn't marginal; will likely have huge impact on whether high-risk groups (outside of hospitals) can be vaccinated widely and quickly.

      2:31 PM - 16 Dec 2020
      • 25 Likes
      • Dave Troy 🇺🇸 Dr. G, who left her house that one time... Oaive Matthew Courtney Kimmie W (((Over Koalified))) Eduardo LopezOrtiz
      8 replies 0 retweets 25 likes
        1. Jo Walker  🏳️‍⚧️‏ @VaccineJo 16 Dec 2020
          Replying to @zeynep @drewconway

          capitalism

          0 replies 0 retweets 1 like
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        2. zeynep tufekci‏Verified account @zeynep 16 Dec 2020
          Replying to @JInterlandi @drewconway

          Yes, even if it required new trials, why not? This is going to be a huge deal for immunizing high-risk groups and for poorer countries especially since mRNA efficacy seems to be significantly higher than the other candidates (that are also good but not as spectacular).

          1 reply 0 retweets 8 likes
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        2. Drew Conway‏Verified account @drewconway 16 Dec 2020
          Replying to @zeynep

          Agreed. I think the question is how to incentivize Moderna to achieve this outcome you know, beyond the obvious benefit to humanity

          1 reply 0 retweets 3 likes
        3. Vin Crespi‏ @nanqprof 16 Dec 2020
          Replying to @drewconway @zeynep

          If may require re-testing and re-approval at this stage to change the lipid container (as a different RNA may interact differently with it)? Biology can surprise, even if it appears as simple as a swap-out of a component.

          0 replies 0 retweets 0 likes
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        2. ItHasCeasedToBe‏ @CeasedIt 16 Dec 2020
          Replying to @zeynep @drewconway

          It’s basically the only originator IIRC, as the mRNA itself is just the protein’s info

          1 reply 0 retweets 0 likes
        3. ItHasCeasedToBe‏ @CeasedIt 16 Dec 2020
          Replying to @CeasedIt @zeynep @drewconway

          Sorry originator -> differentiator

          0 replies 0 retweets 0 likes
        4. End of conversation
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        2. Proud European from Austria 🇪🇺 🇦🇹  🌏‏ @e2dot7182818284 16 Dec 2020
          Replying to @zeynep @drewconway

          Uğur Şahin/BioNTech stated in an interview recently that they are working on a second generation formulation that is stable at higher temperature (normal refrigeration)

          1 reply 0 retweets 0 likes
        3. Proud European from Austria 🇪🇺 🇦🇹  🌏‏ @e2dot7182818284 16 Dec 2020
          Replying to @e2dot7182818284 @zeynep @drewconway

          Didn't find the video interview again but it is also contained in this report. https://www.benzinga.com/node/18624004 pic.twitter.com/kwUeE9IUqv

          0 replies 0 retweets 1 like
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        1. Paul Rosenzweig‏ @RosenzweigP 16 Dec 2020
          Replying to @zeynep @drewconway

          There is likely to be a license in the future. But remember that the Moderna effort was an experiment -- it might have failed. So Pfizer went with the older, more cumbersome tech and they've designed around it. Retrofitting the new Moderna stuff may be hard.

          0 replies 0 retweets 1 like
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