I hear all the immunologists concerned about durability of protection. OTOH I think a one-dose trial could actually increase confidence even if the results were "less protection after a few months but we can get an extra billion+ people vaccinated in 2021".
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What Michael and I are urging is to have the mindset, now, to start whatever we can to put this on a sound(er) footing—something we should have started earlier. Start recruiting Monday for a volunteer placebo arm for the second dose among lower-risk HCW to be vaccinated, for ex.
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That's a new efficacy study, which can certainly be done but not overnight. We'll have more data to inform this discussion soon. The immunogenicity data will allow us to compare kinetics of response and potential correlates of protection in single- vs two-dose recipients.
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