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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @K_G_Andersen @rvenkayya and

      I hear all the immunologists concerned about durability of protection. OTOH I think a one-dose trial could actually increase confidence even if the results were "less protection after a few months but we can get an extra billion+ people vaccinated in 2021".

      1 reply 0 retweets 7 likes
    2. This Tweet is unavailable.
    3. Stephen Goldstein‏ @stgoldst 11 Dec 2020
      Replying to @K_G_Andersen @zeynep and

      I also think it's possible one dose protection could drop off dramatically after just a few weeks, maybe a couple of months. So I agree we need trials. Doing it without trials could be disastrous.

      1 reply 0 retweets 7 likes
    4. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @stgoldst @K_G_Andersen and

      I agree. I also worry that 2 dose efficacy could drop off dramatically in efficacy. We've only evaluated 2 doses within a couple of months - when plasmablasts were abundant, pumping out tremendous numebrs of antibodies. But all of those plasmablasts die off within a couple months

      3 replies 0 retweets 5 likes
    5. Jon L‏ @JonL8675309 11 Dec 2020
      Replying to @michaelmina_lab @stgoldst and

      Post-plasmablast concerns are interesting, and are not being widely discussed [from what I can see]. Perhaps other experts don't want to cast doubt on duration of vaccine immunity [yet]. But plasmablast could be another reason to increase the time between 1st and 2nd shot?

      1 reply 0 retweets 0 likes
    6. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
      Replying to @JonL8675309 @JonLoflin and

      Coming back to some of @zeynep’s points: I fully agree that the global community is not good at doing rapid applied research to inform recommendations, ref masks, schools, rapid tests. And we need to approach this question with a sense of urgency. 1/

      1 reply 1 retweet 1 like
    7. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
      Replying to @rvenkayya @JonLoflin and

      Many groups are thinking about ways to maximize vaccine supply, including global organizations, regulators, vaccine developers, etc. Given the potential benefit, an accelerated research program into a one-dose and longer two-dose schedule to stretch supply would make sense. 2/

      1 reply 1 retweet 4 likes
    8. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
      Replying to @rvenkayya @JonLoflin and

      That said, there are good reasons to believe a one-dose schedule may not be as efficacious as a two-dose schedule, including against severe disease in high-risk populations, due to magnitude, duration and quality of the immune response. 3/

      1 reply 1 retweet 5 likes
    9. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
      Replying to @rvenkayya @JonLoflin and

      No one here is saying one dose is as good as two, but some may interpret early efficacy to mean one dose is sufficient, for all vaccines, before we have any data. We need to be clear about what we do and don’t know and prepare people for revised guidance as we learn more. 4/

      1 reply 1 retweet 4 likes
    10. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @rvenkayya @JonLoflin and

      I'd say the way to figure out the "some may" risk is to communicate clearly, not avoid the trade-off discussion. One twist for this is the age risk is well-defined and exponential so we can make sure to communicate that. (In fact, more boosters for 65+? Anyone looking at that?)

      1 reply 0 retweets 4 likes
      zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @zeynep @rvenkayya and

      I get durability risk without booster(s?) but severe disease is not equally distributed, and dampening the outbreak rapidly is worth a lot (both the disease risk and the downsides to the world of this situation). If we don't put this on agenda now, it won't even be considered.

      1:19 PM - 11 Dec 2020
      • 4 Likes
      • Linn Marie Jon L Charlotte Marshall, MPH
      1 reply 0 retweets 4 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
          Replying to @zeynep @rvenkayya and

          What Michael and I are urging is to have the mindset, now, to start whatever we can to put this on a sound(er) footing—something we should have started earlier. Start recruiting Monday for a volunteer placebo arm for the second dose among lower-risk HCW to be vaccinated, for ex.

          1 reply 0 retweets 4 likes
        3. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
          Replying to @zeynep @JonLoflin and

          That's a new efficacy study, which can certainly be done but not overnight. We'll have more data to inform this discussion soon. The immunogenicity data will allow us to compare kinetics of response and potential correlates of protection in single- vs two-dose recipients.

          1 reply 0 retweets 2 likes
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