I hear all the immunologists concerned about durability of protection. OTOH I think a one-dose trial could actually increase confidence even if the results were "less protection after a few months but we can get an extra billion+ people vaccinated in 2021".
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I get durability risk without booster(s?) but severe disease is not equally distributed, and dampening the outbreak rapidly is worth a lot (both the disease risk and the downsides to the world of this situation). If we don't put this on agenda now, it won't even be considered.
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What Michael and I are urging is to have the mindset, now, to start whatever we can to put this on a sound(er) footing—something we should have started earlier. Start recruiting Monday for a volunteer placebo arm for the second dose among lower-risk HCW to be vaccinated, for ex.
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