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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
      Replying to @zeynep @michaelmina_lab @CarlosdelRio7

      Yes, this is exactly what is meant by a follow on study to assess the non-inferiority of a single dose. I think we’re all saying the same thing! This is worth studying further in a rigorous trial. But I don’t think we should tinker with the current rollout for EUA populations.

      4 replies 2 retweets 49 likes
    2. Stephen Goldstein‏ @stgoldst 11 Dec 2020
      Replying to @nataliexdean @zeynep and

      The concern I have with this is the phase I data showing high total IgG titer but low nAb. Short term protection after dose 1 may be due to high levels of lower quality Abs, whereas much more potent Abs after 2nd dose may provide good longer term protection, plus the higher nAb

      2 replies 0 retweets 6 likes
    3. David Ridley‏ @RidleyDM 11 Dec 2020
      Replying to @stgoldst @nataliexdean and

      All of this strikes me as reason to risk just-in-time delivery of a timely shot #2 (so more people can get vaccinated sooner) if that seems likely to be fulfilled on time, but not strong enough data to change regimens and forgo shot #2.

      1 reply 0 retweets 5 likes
    4. Audi Kiskowski Byrne‏ @a_haema 11 Dec 2020
      Replying to @RidleyDM @stgoldst and

      This seems better for optics as well. The plan is to give the second shot, but if we ran out of vaccine due to unmet deadlines, at least we get the pandemic far more under control while waiting for more doses in the pipeline.

      1 reply 0 retweets 2 likes
    5. David Ridley‏ @RidleyDM 11 Dec 2020
      Replying to @a_haema @stgoldst and

      Yes, that's an important point. "We did a clinical trial but decided to take a guess at an alternative regimen" is not the way to start a campaign about how safe and well tested vaccines are.

      1 reply 0 retweets 23 likes
    6. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
      Replying to @RidleyDM @a_haema and

      I wish I could like this more than once.

      2 replies 0 retweets 19 likes
    7. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @nataliexdean @RidleyDM and

      Sociologically speaking, of course we can't start with "we didn't test this" but I think we can certainly start with rapid trial and intermediate data, along with explaining the trade-offs. The public mistrusts arrogance and lack of transparency, not complexity and honesty.

      2 replies 1 retweet 7 likes
    8. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @zeynep @nataliexdean and

      I think the medical profession (not addressing you guys at all!) really conflates these. They assume we can't tell people about uncertainty and trade-offs and then we end up in suboptimal positions, but we don't even get the trust because complexity/uncertainty isn't the problem.

      1 reply 0 retweets 13 likes
    9. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @zeynep @nataliexdean and

      My guess is that if we had prelim data & asked for volunteers in non high-risk groups (for example, HCW: risk by exposure status not age), we'd be surprised by the update. The public can absolutely follow discussions of trade-offs under uncertainty if it's truly transparent.

      2 replies 0 retweets 13 likes
    10. Steven J. Frisch‏ @stevenjfrisch 11 Dec 2020
      Replying to @zeynep @nataliexdean and

      There is a meaningful percentage of the country's population who are certain that COVID-19 is a hoax and there's a larger percentage, perhaps ~50% of the population, who are likely to refuse vaccination, at least initially. It's easy to overestimate the audience.

      1 reply 0 retweets 0 likes
      zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @stevenjfrisch @nataliexdean and

      Those numbers are at that scale exactly because of a history of *underestimating* the audience which is then worsened by the deliberate misinformation. There is a history here. If you don't trust people, they will never trust you back.

      6:55 AM - 11 Dec 2020
      • 1 Like
      • Steven J. Frisch
      1 reply 0 retweets 1 like
        1. New conversation
        2. Steven J. Frisch‏ @stevenjfrisch 11 Dec 2020
          Replying to @zeynep @nataliexdean and

          I would argue that Trump and his predecessors in propaganda leverage a simple truth: a large percentage of society are both easily seduced by lies and also impervious to factual arguments as an antidote.

          1 reply 0 retweets 1 like
        3. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
          Replying to @stevenjfrisch @nataliexdean and

          In contrast, I think the sentiment expressed above is exactly why we're failing to compete with lies despite extraordinary scientific achievements, like vaccines. For one thing, it's not lack of trust in facts, it's lack of trust in experts. +

          1 reply 0 retweets 1 like
        4. Show replies

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