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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Michael Mina‏Verified account @michaelmina_lab 10 Dec 2020

      Michael Mina Retweeted zeynep tufekci

      Agree! One dose = 2x people vaccinated The math is plain & simple Approach is broken. We do not do what makes sense: w/ rapid tests or making single dose vacc a priority when they work (both obvious benefits). We fail to do what's smart We choose perfect over most effective.https://twitter.com/zeynep/status/1337047714341785605 …

      Michael Mina added,

      zeynep tufekciVerified account @zeynep
      The BioNTech/Pfizer data is out—NEJM & FDA report. I understand this wasn't in the design & the long-term protection from single dose is open question. But given this sharp drop after 14 days after one dose, can someone explain why single dose isn't very very high on the agenda? pic.twitter.com/sxqwACGulz
      Show this thread
      47 replies 170 retweets 795 likes
      Show this thread
    2. Carlos del Rio‏Verified account @CarlosdelRio7 11 Dec 2020
      Replying to @michaelmina_lab

      It will be an absolute disaster if a large number of people only take one dose of the vaccine. It is very likely that protective immunity will wane rapidly in individuals who only take the first shot and efficacy will be nowhere near the 95% reported after the two-dose regimen.

      11 replies 17 retweets 171 likes
    3. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
      Replying to @CarlosdelRio7 @michaelmina_lab

      I agree. Too much uncertainty in short- and long-term efficacy. And the optics of changing the plan now, for a regimen that hasn’t been tested directly, are not great. Follow on studies can assess non-inferiority of a one dose regimen, but for now the data support two doses.

      8 replies 3 retweets 99 likes
    4. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @nataliexdean @CarlosdelRio7

      Yes, the data support two doses. I agree. The data that we have also may support one dose. I'm the first to say that we don't have good data - even w two doses - that go out past a few months. I'm terrified that efficacy will fall fast once plasmablasts die off. 1/

      3 replies 1 retweet 37 likes
    5. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @michaelmina_lab @nataliexdean @CarlosdelRio7

      If we think about this globally - just how difficult its going to be to get the vaccine to most of the world - I do think it is very much worth taking a couple more months and trying the same study in people who otherwise wouldn't be first in line. We can only gain from it. 2/2

      4 replies 1 retweet 28 likes
    6. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @michaelmina_lab @nataliexdean @CarlosdelRio7

      What about an immediate call for volunteers for a randomized group among the many millions who'll get the first shot? Data-wise, some of the initial groups aren't that high risk at the moment (<65 HCWs). The vaccine shortage is going to have huge implications on overall deaths.

      2 replies 6 retweets 27 likes
    7. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
      Replying to @zeynep @michaelmina_lab @CarlosdelRio7

      Yes, this is exactly what is meant by a follow on study to assess the non-inferiority of a single dose. I think we’re all saying the same thing! This is worth studying further in a rigorous trial. But I don’t think we should tinker with the current rollout for EUA populations.

      4 replies 2 retweets 49 likes
    8. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @nataliexdean @zeynep @CarlosdelRio7

      Agree. And we should remain open to change SHOULD additional studies suggest it is better for public health. I worry once we get something set, its incredibly difficult to change. Heck, we can't even get FDA to recognize that antigen tests don't look for residual RNA.

      3 replies 2 retweets 19 likes
      zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @michaelmina_lab @nataliexdean @CarlosdelRio7

      Exactly. I think the idea that single dose may offer a reasonable, potentially excellent, trade-off is something to get out there right now because once something is set as standard, it's practically impossible to change even if it means billions are denied vaccination in 2021.

      6:21 AM - 11 Dec 2020
      • 2 Retweets
      • 14 Likes
      • Iman 🥔 Baghai 🏴‍☠️🇺🇸🥔 Jon L Nathan Goode Malcolm S Linn Marie Youyang Gu Adam Peace Cat Mona van der Smitte #stayathome 😷 💉 #staysafe
      1 reply 2 retweets 14 likes
        1. New conversation
        2. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
          Replying to @zeynep @michaelmina_lab and

          Rajeev Venkayya MD Retweeted Prof. Akiko Iwasaki

          Agree with supply urgency, but wouldn't overstate what we know about efficacy of a single dose. Second dose is likely to help with *magnitude* and *quality* of immune response through affinity maturation. 1/https://twitter.com/VirusesImmunity/status/1336323016737755142?s=20 …

          Rajeev Venkayya MD added,

          Prof. Akiko IwasakiVerified account @VirusesImmunity
          The estimated vaccine efficacy after the 1st (82%), between 1st and 2nd (52.4%) and after the second dose (95%) are all impressive! However, high affinity Ab and long term immunity likely require the 2nd dose and we should all adhere to the recommended regimen. (2/n) pic.twitter.com/hSmSURkVTD
          Show this thread
          1 reply 0 retweets 4 likes
        3. Rajeev Venkayya MD‏Verified account @rvenkayya 11 Dec 2020
          Replying to @rvenkayya @zeynep and

          Rajeev Venkayya MD Retweeted Deepta Bhattacharya

          The good news is that we can study “missed 2nd dose” in the Ph3 and post-authorization populations, and hope to have a correlate of protection soon to make single dose studies easier without efficacy studies. 2/https://twitter.com/deeptabhattacha/status/1337147845686611968?s=20 …

          Rajeev Venkayya MD added,

          Deepta Bhattacharya @deeptabhattacha
          After the second Pfizer dose, the nAb titers go up 10-20-fold (https://www.nejm.org/doi/full/10.1056/NEJMoa2027906 …). That leaves a lot of room for decline while still maintaining protection. Even if every antibody-producing cell died en masse, all at once, the
          Show this thread
          1 reply 1 retweet 8 likes
        4. Show replies

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