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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Michael Mina‏Verified account @michaelmina_lab 10 Dec 2020

      Michael Mina Retweeted zeynep tufekci

      Agree! One dose = 2x people vaccinated The math is plain & simple Approach is broken. We do not do what makes sense: w/ rapid tests or making single dose vacc a priority when they work (both obvious benefits). We fail to do what's smart We choose perfect over most effective.https://twitter.com/zeynep/status/1337047714341785605 …

      Michael Mina added,

      zeynep tufekciVerified account @zeynep
      The BioNTech/Pfizer data is out—NEJM & FDA report. I understand this wasn't in the design & the long-term protection from single dose is open question. But given this sharp drop after 14 days after one dose, can someone explain why single dose isn't very very high on the agenda? pic.twitter.com/sxqwACGulz
      Show this thread
      47 replies 170 retweets 795 likes
      Show this thread
    2. Carlos del Rio‏Verified account @CarlosdelRio7 11 Dec 2020
      Replying to @michaelmina_lab

      It will be an absolute disaster if a large number of people only take one dose of the vaccine. It is very likely that protective immunity will wane rapidly in individuals who only take the first shot and efficacy will be nowhere near the 95% reported after the two-dose regimen.

      11 replies 17 retweets 171 likes
    3. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
      Replying to @CarlosdelRio7 @michaelmina_lab

      I agree. Too much uncertainty in short- and long-term efficacy. And the optics of changing the plan now, for a regimen that hasn’t been tested directly, are not great. Follow on studies can assess non-inferiority of a one dose regimen, but for now the data support two doses.

      8 replies 3 retweets 99 likes
    4. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @nataliexdean @CarlosdelRio7

      Yes, the data support two doses. I agree. The data that we have also may support one dose. I'm the first to say that we don't have good data - even w two doses - that go out past a few months. I'm terrified that efficacy will fall fast once plasmablasts die off. 1/

      3 replies 1 retweet 37 likes
    5. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
      Replying to @michaelmina_lab @nataliexdean @CarlosdelRio7

      If we think about this globally - just how difficult its going to be to get the vaccine to most of the world - I do think it is very much worth taking a couple more months and trying the same study in people who otherwise wouldn't be first in line. We can only gain from it. 2/2

      4 replies 1 retweet 28 likes
      zeynep tufekci‏Verified account @zeynep 11 Dec 2020
      Replying to @michaelmina_lab @nataliexdean @CarlosdelRio7

      What about an immediate call for volunteers for a randomized group among the many millions who'll get the first shot? Data-wise, some of the initial groups aren't that high risk at the moment (<65 HCWs). The vaccine shortage is going to have huge implications on overall deaths.

      5:47 AM - 11 Dec 2020
      • 6 Retweets
      • 27 Likes
      • Jon L Malcolm S Raj Mehta blah _katiesaurus_ Linn Marie 🇺🇸🏳️‍🌈BLESSED BE THE FRUIT LOOPS🏴‍☠️🦍 David Andersen 💉💉💉🎉 The Cats Serf 💉😷
      2 replies 6 retweets 27 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 11 Dec 2020
          Replying to @zeynep @michaelmina_lab and

          I hear all the hesitations, but the other side of the equation—potentially doubling the number vaccinated in the short term—is not a minor number.

          3 replies 0 retweets 12 likes
        3. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
          Replying to @zeynep @nataliexdean @CarlosdelRio7

          Or we simply set up a single dose trial in people unlikely to receive a vaccine until May or June. It will help inform the approach for the world and will give terrific medium term information.

          1 reply 3 retweets 25 likes
        4. Show replies
        1. New conversation
        2. Natalie E. Dean, PhD‏Verified account @nataliexdean 11 Dec 2020
          Replying to @zeynep @michaelmina_lab @CarlosdelRio7

          Yes, this is exactly what is meant by a follow on study to assess the non-inferiority of a single dose. I think we’re all saying the same thing! This is worth studying further in a rigorous trial. But I don’t think we should tinker with the current rollout for EUA populations.

          4 replies 2 retweets 49 likes
        3. Michael Mina‏Verified account @michaelmina_lab 11 Dec 2020
          Replying to @nataliexdean @zeynep @CarlosdelRio7

          Agree. And we should remain open to change SHOULD additional studies suggest it is better for public health. I worry once we get something set, its incredibly difficult to change. Heck, we can't even get FDA to recognize that antigen tests don't look for residual RNA.

          3 replies 2 retweets 19 likes
        4. Show replies

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