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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      zeynep tufekci Retweeted Stefan Baral

      Yeah, but given the stakes, "we don't know for sure so we won't vaccinate hundreds of millions" is not an acceptable answer. Shortage is a terrible trade-off, too. Why didn't they/we immediately launch a single dose trial after prelim data? They knew.https://twitter.com/sdbaral/status/1337053741015502850 …

      zeynep tufekci added,

      Stefan BaralVerified account @sdbaral
      Replying to @zeynep
      Dose de-escalation/non-inferiority trials tend to be very difficult to get pharma to agree to. But indeed, it is an open question of the non-inferiority of 6 weeks after one dose vs 2 weeks after the 2nd dose. Imagine Pfizer/moderna fights back on behalf of their shareholders.
      14 replies 24 retweets 219 likes
      Show this thread
    2. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      Look, folks, like all things pandemic, this is a trade-off. The immunology people should weigh in and explain to us about one side of the trade-off. The other side is a societal/ethical decision because we're bouncing potentially less efficacious against *not at all vaccinated*.

      14 replies 22 retweets 272 likes
      Show this thread
    3. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      This is immediately consequential. US plans to HOLD BACK for many millions now vaccination to preserve for second dose later. @ScottGottliebMD—Pfizer board member—disagrees: "We should get as many shots in our arms as possible right now." https://www.usatoday.com/story/news/health/2020/12/07/covid-vaccine-pfizer-board-member-disagrees-us-distribution-plan/3860363001/ …pic.twitter.com/6CGpcLlsSb

      26 replies 145 retweets 548 likes
      Show this thread
    4. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      zeynep tufekci Retweeted Michael Mina

      Let me ask this. We know older people need the booster more (from published data). But why we wouldn't launch a single-dose effort (randomized/blinded within) for <65 which can answer the questions about durability while immunizing millions more?https://twitter.com/michaelmina_lab/status/1337078184597217281 …

      zeynep tufekci added,

      Michael MinaVerified account @michaelmina_lab
      Agree! One dose = 2x people vaccinated The math is plain & simple Approach is broken. We do not do what makes sense: w/ rapid tests or making single dose vacc a priority when they work (both obvious benefits). We fail to do what's smart We choose perfect over most effective. https://twitter.com/zeynep/status/1337047714341785605 …
      Show this thread
      9 replies 21 retweets 194 likes
      Show this thread
    5. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      I wrote up the case for launching immediate trials to test a single-dose regime. Calling for volunteers among < 65 health-care workers for single dose and later booster seems like the minimal prudent response to this chart. We could know fairly quickly.https://zeynep.substack.com/p/vaccines-and-decision-making-with …

      9 replies 49 retweets 162 likes
      Show this thread
    6. Alex Merz‏ @Merz 10 Dec 2020
      Replying to @zeynep

      Worth noting that no mRNA vaccine has ever been widely deployed for humans before. There was not a strong a priori reason to think that these vaccines would be even close to this efficacious. It was not clear that they would be protective at all.

      1 reply 0 retweets 9 likes
    7. Alex Merz‏ @Merz 10 Dec 2020
      Replying to @Merz @zeynep

      Consequently, when designing the trials, it would have arguably been foolish to waste statistical power on inoculation regimes likely to show borderline protective effect, given what was known at the time.

      1 reply 0 retweets 7 likes
    8. zeynep tufekci‏Verified account @zeynep 10 Dec 2020
      Replying to @Merz

      Absolutely. Plus people were saying even a two year timeline was too optimistic. Do hoorah! On the other hand, they had this initial data months ago? If they had started then, we would already know by the time the second dose will come up. I wish we were more nimble in testing.

      1 reply 0 retweets 3 likes
    9. zeynep tufekci‏Verified account @zeynep 10 Dec 2020
      Replying to @zeynep @Merz

      I understand having the trial go for clearing the bar. I don’t understand why we are not a lot more aggressive with having more trials as quickly as possible given how much this is costing, both human and other costs.

      1 reply 0 retweets 3 likes
    10. Alex Merz‏ @Merz 10 Dec 2020
      Replying to @zeynep

      Because that would require leadership.

      1 reply 0 retweets 3 likes
      zeynep tufekci‏Verified account @zeynep 10 Dec 2020
      Replying to @Merz

      😢

      12:18 PM - 10 Dec 2020
      • 2 Likes
      • Alex Merz
      1 reply 0 retweets 2 likes
        1. New conversation
        2. Alex Merz‏ @Merz 10 Dec 2020
          Replying to @zeynep

          Yeah.

          1 reply 1 retweet 0 likes
        3. Alex Merz‏ @Merz 10 Dec 2020
          Replying to @Merz @zeynep

          It would actually be interesting to see how medical ethicists might deal with such a trial at this juncture since the 2-dose schedule is now standard-of-care.

          2 replies 0 retweets 1 like
        4. Show replies

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