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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      The BioNTech/Pfizer data is out—NEJM & FDA report. I understand this wasn't in the design & the long-term protection from single dose is open question. But given this sharp drop after 14 days after one dose, can someone explain why single dose isn't very very high on the agenda?pic.twitter.com/sxqwACGulz

      78 replies 334 retweets 1,479 likes
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    2. Aaron Richterman, MD‏ @AaronRichterman 10 Dec 2020
      Replying to @zeynep

      Second dose important for overall durable immunity in animal models. This study tells very little about even medium term efficacy of a single dose, unfortunately

      4 replies 3 retweets 42 likes
    3. Roby Bhattacharyya‏ @roby_bhatt 10 Dec 2020
      Replying to @AaronRichterman @zeynep

      Agree. As @zeynep said, the 1256 ppl who got one dose of vaccine are interesting, though not randomly selected. With overall event rate of ~168 out of 18,000 in placebo, upper bound of expected cases would be ~12. That's not a lot to work with, but it's not nothing. (1/2)

      1 reply 0 retweets 3 likes
    4. Roby Bhattacharyya‏ @roby_bhatt 10 Dec 2020
      Replying to @roby_bhatt @AaronRichterman @zeynep

      There were only ~8 cases in vax arm (out of >18,000), so would expect very few in the 1-dose if they stay protected. I don't think we'll know in time, but a single-round while supplies are limited, and catch-up later, would be a very interesting strategy to evaluate if we did.

      1 reply 0 retweets 2 likes
    5. Aaron Richterman, MD‏ @AaronRichterman 10 Dec 2020
      Replying to @roby_bhatt @zeynep

      Seems to me the tricky thing will be that the first doses will go to the highest risk groups. Trying to wrap my head around the biases that would come out of single dosing these populations.

      1 reply 0 retweets 2 likes
      zeynep tufekci‏Verified account @zeynep 10 Dec 2020
      Replying to @AaronRichterman @roby_bhatt

      Yes, that's complicated. Elderly are high-risk but healthcare workers aren't that high-risk right now in comparison, to be honest (given PPE usage in hospital). Could imagine subgroup analyses, randomizing single dose among volunteer healthcare workers. I'd sign up in a second.

      8:06 AM - 10 Dec 2020
      • 2 Likes
      • David Foulser Roby Bhattacharyya
      1 reply 0 retweets 2 likes
        1. New conversation
        2. zeynep tufekci‏Verified account @zeynep 10 Dec 2020
          Replying to @zeynep @AaronRichterman @roby_bhatt

          (to be clear, if I were HCW... I'd sign up for any version of a single dose study based on the above, given the trade off is doubling the number of vaccinated. We'd know in a few months and can resume as per data).

          2 replies 0 retweets 3 likes
        3. Roby Bhattacharyya‏ @roby_bhatt 10 Dec 2020
          Replying to @zeynep @AaronRichterman

          I'm an HCW and would also sign up on the spot for this, w/ longitudinal Ab studies (and serial RT-qPCR) etc.

          1 reply 0 retweets 1 like
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