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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      The BioNTech/Pfizer data is out—NEJM & FDA report. I understand this wasn't in the design & the long-term protection from single dose is open question. But given this sharp drop after 14 days after one dose, can someone explain why single dose isn't very very high on the agenda?pic.twitter.com/sxqwACGulz

      78 replies 334 retweets 1,479 likes
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    2. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      Yes, ideally there would have been a single-dose study as well. But here we are, and with a shortage that will mean many more people will die and everything else will be delayed. Personally, looking at that data, I'd quickly take one dose to give someone else a chance at one.

      17 replies 31 retweets 382 likes
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    3. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      zeynep tufekci Retweeted

      Maybe. There are 1256 people who did not receive the second dose in the trial. Yes, small group but what happened to them? I get it, ideally, we have a single dose study. Not so ideally, we have this data and a severe shortage. Seems worth a discussion. https://twitter.com/Valentine721/status/1337048321026875394 …

      zeynep tufekci added,

      This Tweet is unavailable.
      7 replies 13 retweets 251 likes
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    4. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      Pfizer reports "52.4% efficacy" for single dose but that includes the first seven days, before things kick in, when most new infections happened. At 10-12 days, the chart (eyeballing, no underlying data yet) looks ~80-85% efficacy. Unpleasant trade-off but reality is unpleasant.

      21 replies 48 retweets 430 likes
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    5. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      I'm hoping for immunology/virology people to tell us the potential trade-offs here. We know one side: due to shortages, hundreds of millions of people will not get vaccinated anytime soon. What does the calculation on the other side look like?

      16 replies 17 retweets 260 likes
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    6. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      At a minimum minimum, there should be an immediate single-dose trial launched, like yesterday. We sadly have a raging epidemic and will get results quickly but I think not giving this real thought now—and an explanation to the public—would be a grave mistake, given the stakes.

      12 replies 32 retweets 343 likes
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    7. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      zeynep tufekci Retweeted Stefan Baral

      Yeah, but given the stakes, "we don't know for sure so we won't vaccinate hundreds of millions" is not an acceptable answer. Shortage is a terrible trade-off, too. Why didn't they/we immediately launch a single dose trial after prelim data? They knew.https://twitter.com/sdbaral/status/1337053741015502850 …

      zeynep tufekci added,

      Stefan BaralVerified account @sdbaral
      Replying to @zeynep
      Dose de-escalation/non-inferiority trials tend to be very difficult to get pharma to agree to. But indeed, it is an open question of the non-inferiority of 6 weeks after one dose vs 2 weeks after the 2nd dose. Imagine Pfizer/moderna fights back on behalf of their shareholders.
      14 replies 24 retweets 219 likes
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    8. zeynep tufekci‏Verified account @zeynep 10 Dec 2020

      Look, folks, like all things pandemic, this is a trade-off. The immunology people should weigh in and explain to us about one side of the trade-off. The other side is a societal/ethical decision because we're bouncing potentially less efficacious against *not at all vaccinated*.

      14 replies 22 retweets 272 likes
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      zeynep tufekci‏Verified account @zeynep 10 Dec 2020
      Replying to @nicholas_bagley

      Yeah. It's kind of maddening to treat these questions as if there is one ideal, scientific answer, rather than messy trade-offs and incomplete data on all sides.

      7:44 AM - 10 Dec 2020
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      3 replies 0 retweets 16 likes
        1. Nicholas Bauer, PhD  👨‍🔬 🔬‏ @BioTurboNick 10 Dec 2020
          Replying to @zeynep @nicholas_bagley

          Or don't. We already have the tools to stop death. No need to rush or jury-rig a vaccine in panic.

          0 replies 0 retweets 0 likes
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        1. Rod Hayward‏ @ProfHayward 10 Dec 2020
          Replying to @zeynep @nicholas_bagley

          Agree completely. The cultural barrier is big, however. Medicine has a strong bias abt not extrapolating beyond RCT protocols/pops. This rigid non-scientific anti-logic cultural bias is endemic, & IMO, very destructive.

          1 reply 0 retweets 3 likes
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