Yes, ideally there would have been a single-dose study as well. But here we are, and with a shortage that will mean many more people will die and everything else will be delayed. Personally, looking at that data, I'd quickly take one dose to give someone else a chance at one.
-
Show this thread
-
zeynep tufekci Retweeted
Maybe. There are 1256 people who did not receive the second dose in the trial. Yes, small group but what happened to them? I get it, ideally, we have a single dose study. Not so ideally, we have this data and a severe shortage. Seems worth a discussion. https://twitter.com/Valentine721/status/1337048321026875394 …
zeynep tufekci added,
This Tweet is unavailable.7 replies 13 retweets 251 likesShow this thread -
Pfizer reports "52.4% efficacy" for single dose but that includes the first seven days, before things kick in, when most new infections happened. At 10-12 days, the chart (eyeballing, no underlying data yet) looks ~80-85% efficacy. Unpleasant trade-off but reality is unpleasant.
21 replies 48 retweets 430 likesShow this thread -
I'm hoping for immunology/virology people to tell us the potential trade-offs here. We know one side: due to shortages, hundreds of millions of people will not get vaccinated anytime soon. What does the calculation on the other side look like?
16 replies 17 retweets 260 likesShow this thread -
At a minimum minimum, there should be an immediate single-dose trial launched, like yesterday. We sadly have a raging epidemic and will get results quickly but I think not giving this real thought now—and an explanation to the public—would be a grave mistake, given the stakes.
12 replies 32 retweets 343 likesShow this thread -
Replying to @zeynep
I think it’s a real concern that you’d do that and have people lose protection at 2-3 months, then not have the supply to boost them. Certainly support a single dose trial.
1 reply 0 retweets 3 likes -
also wonder whether a single dose might be less likely to prevent transmission vs preventing symptomatic disease
1 reply 0 retweets 0 likes -
combine the two and you have potential for a 4th wave driven by asymptomatic spread a few months after the vaccine is introduced...
1 reply 0 retweets 0 likes -
Symptomatic spread (what you get without vaccination) is much worse.
1 reply 0 retweets 0 likes -
well, sort of asymptomatic and presymptomatic spread is likely a major reason this virus is so hard to control if it was more like SARS-1 each infection would be worse but we'd have fewer infections
2 replies 0 retweets 2 likes
You can't conflate those two types of spread under a vaccine regime, though.
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.