Reason that past clinical studies, focusing on health-care worker outcomes, are not the best indicator is that masks for *source-control* is not an individual level variable. It's like asking if filters on car exhausts lower air pollution by measuring the air ... inside each car.
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We outline both the logic and previous existing studies for *source control* here. (Current as of few months ago).https://www.preprints.org/manuscript/202004.0203/v2 …
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We've since had natural experiment papers (comparing countries mask wearing/not). For this kind of variable, community-wide rather than individual, that's the best measure. Most of the confusion here is not realizing the source-control can't be measured with individual outcomes.
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How do you randomize something you can't measure at the individual level? It's a population level outcome. But we study many things without randomization. I think lab + natural experiment papers (just starting to come out) will be the best level of evidence for this.
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