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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      When we don't measure important stuff. A thread about the immune response to #SARSCoV2 1. Since serology/IgG can be readily measured, this is what is conventionally used to assess an individual's response That's a very incomplete picture https://www.cell.com/trends/pharmacological-sciences/pdf/S0165-6147(20)30130-9.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0165614720301309%3Fshowall%3Dtrue …pic.twitter.com/IKSlrrGpXh

      37 replies 719 retweets 1,406 likes
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    2. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      2. Just because T cell repertoire isn't measured, except for research purposes, doesn't mean it's not important. Very important. Like in this recent @SciImmunology paper that showed the #SARSCoV2-specific T cell response in patients with ARDS https://immunology.sciencemag.org/content/5/48/eabd2071 …pic.twitter.com/diBqNEYvMO

      2 replies 60 retweets 206 likes
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    3. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      3. So many studies have reported IgG, IgM but provide no insight on T-cell mediated immunity, no less serially assess this over time. A good example is this excellent recent paper @NatureMedicine in asymptomatic patients https://www.nature.com/articles/s41591-020-0965-6 …pic.twitter.com/3ZIA8Ugkzb

      3 replies 54 retweets 188 likes
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    4. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      4. Yet posts like this appeared yesterday, reverberate widely (not even a link to the study), and are impossible to interpretpic.twitter.com/tA1jALEHzF

      7 replies 24 retweets 163 likes
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    5. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      5. One of the best studies to show the importance of T-cell immunity was published in @CellCellPress https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3 … In some people there was a pre-existing T-cell response to #SARSCoV2, cross-reactive from other coronaviruses; only rough correlated w/ the Ab responsepic.twitter.com/njSv85H87O

      1 reply 72 retweets 242 likes
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    6. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      6. Today this got even a bit more complicated. It's not just T cells that respond to a virus. https://media.nature.com/original/magazine-assets/d41586-020-01916-2/d41586-020-01916-2.pdf … @NatureNV https://www.nature.com/articles/s41586-020-2424-4 … @naturepic.twitter.com/iogG83qX4W

      5 replies 75 retweets 239 likes
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    7. Eric Topol‏Verified account @EricTopol 1 Jul 2020

      7. So when you interpret seroprevalence, serology, antibody only data, please keep the incomplete nature of that assessment in terms of the broader cellular immune response to #SARSCoV2. There's a lot more to learn about the stuff we don't measure.

      30 replies 82 retweets 358 likes
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      zeynep tufekci‏Verified account @zeynep 1 Jul 2020
      Replying to @EricTopol

      There is a "no immunity!!!🚨🚨" headline or viral tweet every week. I'll panic if we start seeing for real re-infections. I keep saying this, but very frustrated by how we went from "it's just the flu" to "it's supermutantninjavirus" so quickly.

      6:40 PM - 1 Jul 2020
      • 1 Retweet
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      • Gingerbread Person. Ryan Madrid John Covil Seha Ismen Ozgur Anne Marie Wissman
      2 replies 1 retweet 7 likes
        1. Ryan Madrid‏ @Wearashirt 2 Jul 2020
          Replying to @zeynep @EricTopol

          coronabungga dude

          0 replies 0 retweets 0 likes
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