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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 16 Jun 2020

      ‼️ Very, very good news. Dexamethasone, a cheap corticosteroid, greatly reduced death rates for people on respiratory support—35% for ventilator, 20% for O2—in a RANDOMIZED TRIAL. The FIRST drug to improve survival. This is why we try to delay the curve. https://www.recoverytrial.net/files/recovery_dexamethasone_statement_160620_final.pdf …pic.twitter.com/LBMa9rszmz

      49 replies 1,330 retweets 3,974 likes
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    2. zeynep tufekci‏Verified account @zeynep 16 Jun 2020

      Dexamthasone result is from the Oxford/NHS RECOVERY trial in the UK. A really good part of the UK response. Unlike the many confusing, low-quality hydroxychloroquine trials, this one is randomized. Next pandemic, we should start randomized trials on day one. Will save many lives.

      3 replies 55 retweets 314 likes
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    3. zeynep tufekci‏Verified account @zeynep 16 Jun 2020

      zeynep tufekci Retweeted Peter Horby

      The UK RECOVERY trial also finally gave us conclusive results about hydroxychloroquine—that there don't seem to be any benefits. We need randomized trials as early as possible. We also need to contain this virus as long as possible, to develop therapies.https://twitter.com/PeterHorby/status/1268911348366409730 …

      zeynep tufekci added,

      Peter Horby @PeterHorby
      pic.twitter.com/lvASrvekMb
      6 replies 29 retweets 171 likes
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    4. zeynep tufekci‏Verified account @zeynep 16 Jun 2020

      Our only proven drug to date, remdesivir—an expensive drug in short supply—was only shown to reduce time to recovery among the hospitalized by four days. I mean, yeay! Better than nothing. But dexamethasone—a cheap, common drug— show to be saving lives is a real breakthrough.

      7 replies 37 retweets 205 likes
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    5. zeynep tufekci‏Verified account @zeynep 16 Jun 2020

      Also, media:. Please emphasize solid RCT data shows no dexamethasone benefit to people not on respiratory support. Not useful till people need ventilator or oxygen. No logic to hoarding or prophylactic use. Corticosteroids suppress the immune system. Not to be taken willy-nilly.pic.twitter.com/PcIdT7dUsc

      6 replies 150 retweets 421 likes
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    6. Adam Buck‏ @AdBuck 16 Jun 2020
      Replying to @zeynep

      You haven’t seen the pre-print yet so perhaps we should all avoid being too definitive about its subgroup analysis? We have no idea how well powered it was for the not on oxygen group.

      1 reply 0 retweets 3 likes
      zeynep tufekci‏Verified account @zeynep 16 Jun 2020
      Replying to @AdBuck

      I think we can confidently say that we have no evidence, yet, for that kind of use. Follow-up is 94% complete and the study seem well-powered but yes there may well be future evidence for earlier use. But till then, it makes sense to avoid the HCQ debacle of overuse.

      6:13 AM - 16 Jun 2020
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      • Phyxis Graham Webster
      0 replies 0 retweets 2 likes

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