That now-retracted study was underpowered to the point of no use *and* it had math and interpretability problems. The opposite of don't publish quackery isn't parrot peer-reviewed studies without reflection. There's a process. It's messy. But it bends towards empirical validity.
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Besides the fact that the Lancet HCQ study was observational with glaring problems of controlling for severity, a randomized trial on HCQ was unblinded as a result and found no harms. That's a very loud signal. I tried to warn and got a lot of push-back.https://twitter.com/zeynep/status/1264671101587804172 …
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Just like the non evidence-based beach/park shaming, the sensationalized & rushed reporting of and social media reaction to potential HCQ harms will do enormous harm to what we do need: more science, but one that is seen through a messy but now strikingly robust and fast process.
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Find the people who didn't; find the people who try to fight their own instincts and ideological priors; find the people who admit errors. The last one might be the most important. Errors are unavoidable. It's the process that works, not any single stance.https://twitter.com/LJAkaar67/status/1268185055546900480 …
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Aaaand, that Lancet HCQ harms study is retracted. Again, please do note that the study had quickly raised concerns among the scientific community. It contradicted existing knowledge. There was an open letter by prominent scientists from top universities.https://twitter.com/TheLancet/status/1268613313702891523 …
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End of conversation
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Has Lancet been too quick to publish lately and/or in past? I’m also thinking this and recent retractions and the anti-vac study that was retracted some years ago.
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Lancet publishing this is symptomatic of the root problem: peer review as constructed is designed to improve studies submitted in good faith; it's poorly equipped to catch outright fraud. We need open science and open data to expose fraud like thishttps://twitter.com/alexjcarroll/status/1268171594238746624 …
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