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zeynep's profile
zeynep tufekci
zeynep tufekci
zeynep tufekci
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@zeynep

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zeynep tufekciVerified account

@zeynep

Complex systems, wicked problems. Society, technology, science and more. @UNC professor. @NYTimes columnist. My newsletter is @insight: http://www.theinsight.org 

floating in a most peculiar way
theinsight.org
Joined August 2009

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    1. zeynep tufekci‏Verified account @zeynep 24 May 2020

      zeynep tufekci Retweeted Ramin Farzaneh-Far MD

      People should stop making scary declarations about HCQ. As of yet, there is no evidence of harm. The observational studies are good to have, but there are actual randomized trials going on. They urgently checked and found *no* indication of harm, yet, and the trial is continuing.https://twitter.com/rfsquared/status/1264638707916832768 …

      zeynep tufekci added,

      Ramin Farzaneh-Far MD @rfsquared
      Following an urgent unblinded look at HCQ data “...the Data Monitoring Committee saw no cogent reason to suspend recruitment for safety reasons and recommended the trial continue recruitment without interruption.” https://twitter.com/califf001/status/1264636314504138752 …
      9 replies 29 retweets 104 likes
      Show this thread
    2. Mark Gubrud‏ @mgubrud 24 May 2020
      Replying to @zeynep

      96,032 patients, 671 hospitals, 6 continents. "our findings suggest not only an absence of therapeutic benefit but also potential harm with the use of hydroxychloroquine or chloroquine drug regimens" https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2931180-6 …pic.twitter.com/E2pCDHXZoR

      3 replies 0 retweets 15 likes
    3. Ryan Radia‏ @RyanRadia 24 May 2020
      Replying to @mgubrud @zeynep

      Right, this is a troubling large observational study, but the more important question is what RCTs reveal.

      2 replies 0 retweets 1 like
      zeynep tufekci‏Verified account @zeynep 24 May 2020
      Replying to @RyanRadia @mgubrud

      Yes, people who actually understand the difference have urgently checked the ongoing RCTs and found no harm to justify stopping the trials. History is full of observational studies being very very wrong. Unfortunately, many people don't understand statistics well enough.

      3:02 PM - 24 May 2020
      • 2 Retweets
      • 5 Likes
      • Paul 'Living in the Crazy Years' Harper Ryan Radia Paromita Roy Jenny Kim
      3 replies 2 retweets 5 likes
        1. New conversation
        2. Mark Gubrud‏ @mgubrud 24 May 2020
          Replying to @zeynep @RyanRadia

          The only explanation for the results that a true RCT would eliminate is that some preselective bias caused people with a heightened risk of ventricular arrythmias to be placed on drugs known to be capable of increasing that risk. Yes, it could be so. Weirder things have happened.

          0 replies 0 retweets 1 like
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        1. I Brake 4 Ants‏ @ibrake4ants 24 May 2020
          Replying to @zeynep @RyanRadia @mgubrud

          Well I wish that people would’ve added that caveat when they posted the results of that large observational study.

          0 replies 0 retweets 0 likes
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        1. New conversation
        2. Jonah Gelbach‏ @gelbach 24 May 2020
          Replying to @zeynep @RyanRadia @mgubrud

          Asking seriously, because I do not know: are the rcts in question sufficiently powered to detect the kind of harms that would be enough to counterindicate given the number of observations and time elapsed so far? This is distinct from whether they are powered to detect benefits.

          1 reply 0 retweets 3 likes
        3. Zoë McLaren, PhD‏ @ZoeMcLaren 29 May 2020
          Replying to @gelbach @zeynep and

          The harms are required to be reported centrally partly for this reason. So they're powered to detect differential impact.

          0 replies 0 retweets 1 like
        4. End of conversation

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