XANOMELINE + TIOTROPIUM: a pan-muscarinic, polypharmacologic drug plus a peripheral pan-muscarinic antagonist.
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A POTENIALLY YUUGE ADVANCE IN TREATING SCHIZOPHRENIA!!
Karuna Therapeutics Announces KarXT Met Primary Endpoint in Phase 2 Clinical Trial of Acute Psych... https://finance.yahoo.com/news/karuna-therapeutics-announces-karxt-met-110000768.html?soc_src=social-sh&soc_trk=tw … via @YahooFinance
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Was this the secret mechanism of clozapine all this time, hidden in plain sight?
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Clozapine is an antagonist
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I know xanomeline failed in AD but I wonder whether it would do better combined with a peripheral antagonist as in this formulation
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Old(er) people (especially men) tend not to tolerate muscarinic blockers.
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It's a good time to be a schizophrenic
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Is 11.6 point mean reduction in total Positive and Negative Syndrome Scale (PANSS) score, a lot?
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