PI pretending they're leading the graduate student #holdOnForDearLife
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Isaac Kohane
@zakkohane
Computer science + Biomedicine = Medicine as a Knowledge Processing Discipline Prof/Dept Chair zaklab.org MD/PhD
Isaac Kohane’s Tweets
Seems like determined work at EU to monitor all online conversations. is this as bad as it is portrayed?
Illuminating and fun (and at times high entropy!) conversation with Michael Abramoff and coming to Grand Rounds soon
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I am keenly aware of the shortage of donor organs. Coercing a vulnerable population is not the way…. miamiherald.com/news/nation-wo
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Expert systems of the 2020s? Presently medically applied LLMs are trained on human behavior largely transduced by online text (not raw biomedical data). If you squint, is it mechanism of implementing the fever dream we had in the 1980s of scaling human expertise?
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Bumped into the man, the legend while on our respective walks.
Fun fact: my stint in Atul’s lab at Stanford definitely altered my grad school trajectory. I was thinking of quitting prior to starting work in the lab.
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Stunned and thrilled to be one of the 505 scientists, engineers and innovators from around the world and across all disciplines elected into the 2022 class of Fellows! Thank you to all my lab members and collaborators, past and present! buff.ly/3Hl1L5K
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Some LLM are more equal than others
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Gave this sleek new clinical tool a spin.
The ddx explanations are articulate but hilariously wrong - classic LLM smoke and mirrors.
If a med student read this A/P on rounds, they would never live it down 
twitter.com/GlassHealthHQ/…
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Too few US healthcare systems can provide this kind of basic morbidity accounting. Without it, rational health policy becomes a fever dream. HT
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1/7 #COVID19 update from our 5 academic med centers: 19,706 #SARSCoV2 positive patients admitted to date in our 12 hospitals; 14,554 discharged home to date. @UofCAHealth hospitals cared for 154 #SARSCoV2 positive inpatients yesterday. Some inpatient tests may be pending.
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And canonical examples of class projects gone wild
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Crystal clear examples from @pranavrajpurkar of the shortcuts that machine learning models may take and therefore the need to understand what’s baked into the data used to train your models twitter.com/NEJM_AI/status…
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Data contributions are currently undervalued in AI.
We need more conferences and journals (like NeurIPS datasets and benchmarks & Nature Scientific Data) that give dataset curation the appreciation it deserves!
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Great way to help a patient population who could use the help #raredisease
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AboutLeighSyndrome.com will be a resource for the entire community.
aboutleighsyndrome.com
Would you like to be involved in creating it? Please reach out at info@curemito.org. Patients, medical students, doctors are welcome to join us.
#leighsyndrome #mitochondrialdisese
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Bad for patients and doctors and nurses
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3. To match epic workflow for ORs, TEE patients now go to prep and hold, then “OR”, then PACU
4. After procedure, discharge in EPIC (reconcile meds, discharge instructions and a bajillion other clicks )
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"Generative AI: No humbug" from my usually appropriately and deeply skeptical colleague
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Today reminds me of the importance of the issues described in this paper by still so many flawed case-control studies doing the rounds
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Come by 4:45 to get first dibs on the refreshments. Stay for the enlightenment on entrepreneurship.
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Cool company, cool leader and for the first time in years, in person in our cosy @HMSCountway @harvardmed where we will share refreshments, ideas, and network and then hear the path followed by our featured speaker, Dr. Grossman of Eleven Therapeutics @eleventx twitter.com/HarvardDBMI/st…
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I am still wondering whether the creators of ChatGPT are aware that in French, it means : Cat, I farted
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THAT is the central challenge of clinical AI based on LLM. Until we have principled, preferably information-theoretic answer, human-in-the-loop (to apply common sense, robustness heuristics etc) seems mandatory. Hinton can wait a little longer to stop hiring human domain experts.
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If some statistician/geneticists can tell us what to do in a comprehensible way that would be great. (pretty please?) Even "doing permutations" is multi-pathed options between the fixed and random effects and the rotation/scaling malarky.
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📢 New Clinical LLM alert!
T5-Base & T5-Large models trained from ✨scratch✨ on MIMIC III + IV notes
Check out physionet for access: physionet.org/content/clinic
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Holy smokes! Obvious after the fact but this is just a mere foreshadowing of what application programming is going to be like. The implied interoperability because of malleable data representation is a great point. HT
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We're releasing our @scale_AI hackathon 1st place project - "GPT is all you need for backend" with @evanon0ping @theappletucker
But let me first explain how it works:
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Cool company, cool leader and for the first time in years, in person in our cosy where we will share refreshments, ideas, and network and then hear the path followed by our featured speaker, Dr. Grossman of Eleven Therapeutics
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Join us tomorrow 4:30–6pm IN PERSON or virtually for the next Biomedical Informatics Entrepreneurs Salon #BIES hosted by @zakkohane @harvardmed with @HarvardTechXfer.
Speaker: Dr. Iris Grossman, Chief Strategy Officer @eleventx
Register: eventbrite.com/e/biomedical-i
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Trying to prevent students from using AI is the wrong approach. They will have AI available in their professional lives. Academics should be teaching students how to integrate and validate AI in their work. twitter.com/Nature/status/
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Very impressive HT although not “fully transformer-based” as CNN used to extract features (very reasonable design and does not take away from achievement). interesting to see stratification/therapy selection from H&E stains versus genomics by 2030 (vs combo).
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Very happy to share our latest preprint 
"Fully transformer-based biomarker prediction from #colorectal #cancer histology". This is a massive collaborative study in >9000 patients which is led by @sophiajwagner: arxiv.org/abs/2301.09617 #AI (1/4)
"Fully transformer-based biomarker prediction from #colorectal #cancer histology". This is a massive collaborative study in >9000 patients which is led by @sophiajwagner: arxiv.org/abs/2301.09617 #AI (1/4)Show this thread
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Students are going to have ChatGPT and other AI available in their professional lives. Educators need to focus on how to integrate and validate these tools, not on how to prevent students from using them. twitter.com/RoxanaDaneshjo
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The latest episode of NEJM AI Grand Rounds features , a faculty member of , who has been at the forefront of medical AI his entire career. His group continues to push the frontier of medical AI. Listen to the full episode:
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Excited to teach a course on #biomedical #AI this semester
Follow our course materials, reading lists and paper highlights which we will release throughout the semester
zitniklab.hms.harvard.edu/BMI702
Thankful for star TA team Y Huang
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The excitement about AI is deeper and more disinterested than the excitement about crypto. There's something real to crypto, for sure, but AI seems more likely to be the thing historians consider important about this decade.
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We thank
HE Isaac Herzog
Vice-Provost Mark Elliott
Deans Roberts and Boudreau
Profs. &
For celebrating with us the Jerusalem Inauguration Ceremony of the CRI/HMS #BerkowitzLivingLaboratory
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There is a reason why so many first and second generation immigrant families, including my own, have so few relatives in our extended families. 81 years ago, the Nazi leadership set in motion the systematic destruction of millions of innocent Jewish men, women and children
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A tragic loss for our community
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Obituary: Alma Dal Co (1989–2022)
A visionary and interdisciplinary scientist who brought a fearless passion to everything she did, inspiring all those around her.
nature.com/articles/s4155
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Obituary: Alma Dal Co (1989–2022)
A visionary and interdisciplinary scientist who brought a fearless passion to everything she did, inspiring all those around her.
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‘Data available on request’
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If George Santos was a scientist, what lies would he have told to get a faculty position?
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ChatGPT could have improved the dialogue
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On the next episode of AI Grand Rounds, we sit down with the prodigious Pranav Rajpurkar () to talk about AI in radiology, what he learned about mentorship from , and the impact of large self-supervised models on medicine.
Link:
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Episode 2 of NEJM AI Grand Rounds is here!
and are joined with , an assistant professor who leads a lab focused on developing AI capable of highly complex medical decision making.
Listen now:
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Excited to share our new Grand Rounds episode, an enlightening conversation with of who takes us behind the scenes of a few seminal medical AI papers over the past decade and also gives us a preview of what's next:
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Calimitous Calumny Ken! Ponzi saint by comparison “Despite not knowing her, Ponzi volunteered for 2 major operations to donate 122 square inches (790 cm2) of his skin from his back and legs to Pearl. This resulted in pleurisy and similar complications, and Ponzi losing his job.”
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