People proselytize about the benefits of meditation and psychedelics with no real way of dealing with it when things go south. I don't just mean "an unpleasant experience that is recovered from" I mean protracted malaise and mental illness.
It seems to refer to a prolonged period of depersonalization that is felt as frankly terrifying and unpleasant. Epistemic status: all of this is off the cuff, I haven't done any reading on it for years, and most of that was casual internet browsing.
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There are scattered reports of suicide and psychosis, including in very early Buddhist scriptures.
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There is a lot of talk about the way out being through, leaning into it, crisis as spiritual opportunity, etc.
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