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will_malone's profile
Will Malone MD
Will Malone MD
Will Malone MD
@will_malone

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Will Malone MD

@will_malone

Endocrinologist. Views my own. Society for Evidence-Based Gender Medicine (http://www.segm.org ). ReThink Identity Medicine Ethics (https://rethinkime.org ).

United States
Joined November 2010

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    1. Will Malone MD‏ @will_malone 15 Dec 2020

      Will Malone MD Retweeted Jack Turban MD  🏳️‍🌈 🧠

      Yet again, @jack_turban accuses journalists of “agenda-driven propaganda” & “astounding misinformation.” Jack’s new target is the @TheEconomist ‘s coverage of the UK High Court ruling re: experimental hormonal interventions for gender-dysphoric youth./1 https://segm.org/Keira_Bell_ruling_global_repercussions …https://twitter.com/jack_turban/status/1338919340901462016 …

      Will Malone MD added,

      Jack Turban MD  🏳️‍🌈 🧠Verified account @jack_turban
      The misinformation about #trans youth and #mentalhealth in this piece from @TheEconomist is astounding. Thread (1/9) pic.twitter.com/N64imBg1OA
      Show this thread
      22 replies 210 retweets 610 likes
      Show this thread
    2. Will Malone MD‏ @will_malone 15 Dec 2020

      Jack labels the thorough review of evidence undertaken by the UK High Court and their decision to consider puberty blockers (PBs) an experimental treatment “a blatant disregard for scientific evidence.” Jack lists studies he claims support his position. Let’s #factcheckjack. /2pic.twitter.com/XPpPOVCR6Z

      1 reply 31 retweets 226 likes
      Show this thread
    3. Will Malone MD‏ @will_malone 15 Dec 2020

      Let’s start with de Vries, the “gold standard” 2011 study on which PB usage in gender dysphoric adolescents is based. The results? Puberty blockade didn’t improve #genderdysphoria or body image in boys or girls. /3 https://pubmed.ncbi.nlm.nih.gov/20646177/ pic.twitter.com/aFAoYgPvWk

      3 replies 21 retweets 215 likes
      Show this thread
    4. Will Malone MD‏ @will_malone 15 Dec 2020

      The de Vries 2011 study did show improvements in psychological function w/ PBs over baseline. The authors state they don’t know why these improvements occurred, and that psychological support or other reasons may have helped. This illustrates the need for control groups. /4pic.twitter.com/lWqy2YudSX

      1 reply 7 retweets 162 likes
      Show this thread
    5. Will Malone MD‏ @will_malone 15 Dec 2020

      A recently released UK study attempted to replicate the de Vries study and failed to show any improvements. This failure to replicate research findings is not unique. That’s why single-site uncontrolled studies are considered *low-quality* evidence. /5 https://www.medrxiv.org/content/10.1101/2020.12.01.20241653v1.full …pic.twitter.com/VLk4pBPOKa

      1 reply 13 retweets 200 likes
      Show this thread
    6. Will Malone MD‏ @will_malone 15 Dec 2020

      Moving on to Costa 2015. The study had 2 gps: (psych support) vs (PBs + psych support). Both gps improved at 18 months, but no difference was seen btw the 2 groups, meaning the study provides no evidence PB’s improve psychological functioning. /6 https://www.jsm.jsexmed.org/article/S1743-6095(19)31424-9/fulltext …pic.twitter.com/8GNeuWcgGa

      2 replies 16 retweets 171 likes
      Show this thread
    7. Will Malone MD‏ @will_malone 15 Dec 2020

      Now on to Turban 2020. The paper contributes nothing to our understanding of pubertal blockade. Why? Analysis of a poor-quality online convenience sample with respondents confused by what puberty blockers are, renders meaningless findings. /7 https://link.springer.com/article/10.1007%2Fs10508-020-01743-6 …pic.twitter.com/DahkSM4rbe

      1 reply 13 retweets 174 likes
      Show this thread
    8. Will Malone MD‏ @will_malone 15 Dec 2020

      Although those who mistakenly claimed to have taken PBs were removed from the analysis, this correction wasn’t possible for those in the “wanted PBs but didn’t get them” control arm, compromising the entire analysis. Lack of control for mental health was also a key mistake./8pic.twitter.com/wfQWwO0vlZ

      2 replies 8 retweets 153 likes
      Show this thread
      Will Malone MD‏ @will_malone 15 Dec 2020

      Even if we believe the results of the study’s flawed analysis, those who took puberty blockers were 2x as likely to be hospitalized for suicide attempts than those who didn’t. Not good. (Yes, it did get the “Study of the Year award” by Pediatrics. Will address another time.) /9pic.twitter.com/vdaC9ba9r2

      11:17 PM - 15 Dec 2020
      • 36 Retweets
      • 214 Likes
      • Wicked Which Kerristian Ashley 💛 OTarret 🦏🐘 Jude Reasonably Angry Woman 💜🤍💚 #NoThankYou Actual Female Persephone Ljubow Kollontai
      8 replies 36 retweets 214 likes
        1. New conversation
        2. Will Malone MD‏ @will_malone 15 Dec 2020

          Van der Miesen 2020: Newly-referred 14 yr vs. 17 yr-olds w/ yrs of psych support and on PBs. The latter group did better. New referrals (younger) often come in a crisis. 17-yr-olds are older, had more therapy. Did PBs help? The authors aren’t sure. /10 https://pubmed.ncbi.nlm.nih.gov/32273193/ pic.twitter.com/kuSiXXgeYA

          1 reply 9 retweets 134 likes
          Show this thread
        3. Will Malone MD‏ @will_malone 15 Dec 2020

          Finally, Achille 2020. 50 participants, no control group. The authors say they could not determine whether PBs were the cause of observed changes in psychological function over time. The authors are not overstating their level of confidence—Jack is. /11 https://ijpeonline.biomedcentral.com/articles/10.1186/s13633-020-00078-2 …pic.twitter.com/oKfpB818EG

          1 reply 9 retweets 144 likes
          Show this thread
        4. Will Malone MD‏ @will_malone 15 Dec 2020

          And although Jack does not mention it, there is another alarming finding from the UK GIDS study: while on puberty blockers, girls reported increased self-harming behavior. /12pic.twitter.com/Fui4ywkIEA

          1 reply 31 retweets 187 likes
          Show this thread
        5. Will Malone MD‏ @will_malone 15 Dec 2020

          Then there are surgical issues. Although girls’ future mastectomies may be more minimal, the boys’ vaginoplasties will be more complicated since PBs impeded tissue development. This played out in a very public way for Jazz./13 https://pediatrics.aappublications.org/content/146/5/e20193653 …pic.twitter.com/xMNNzCGbSq

          3 replies 15 retweets 138 likes
          Show this thread
        6. Will Malone MD‏ @will_malone 15 Dec 2020

          To sum up: De Vries showed some improvement in psych function(but not GD). However, the newly released UK GIDS study failed to replicate this. Neither applies to the current wave of adolescent-onset GD. The other 4 studies quoted by Jack fail to support his claim./14

          3 replies 15 retweets 170 likes
          Show this thread
        7. Will Malone MD‏ @will_malone 15 Dec 2020

          The UK Court reached the correct conclusion: puberty blockers are experimental. While other sources are silent regarding this decision or propagate false #genderfolklore, @TheEconomist provided nuanced and accurate coverage for which many are grateful. /15

          18 replies 56 retweets 351 likes
          Show this thread
        8. End of conversation
        1. New conversation
        2. Mark Schirmer‏ @MarkSchirmer4 22 Dec 2020
          Replying to @will_malone @drgypsy

          As I understand the drug, a substantial side effect is increased depression. So we are giving drugs that increase depression to a group that is probably already depressed?

          2 replies 0 retweets 3 likes
        3. Show replies
        1.  🏁The ballwaxing menstruatrix 🤐 🕷️ ⬛️ 🟧‏ @cheesyredrocket Apr 3
          Replying to @will_malone

          Did you ever tweet about why this paper got this award?

          0 replies 0 retweets 2 likes
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        1. Dachshund Chowder‏ @DoggoDomination Apr 3
          Replying to @will_malone

          pic.twitter.com/WnvFdvQWLL

          0 replies 0 retweets 4 likes
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