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whitequark's profile
whitequark
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@whitequark

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whitequark

@whitequark

http://whitequark.org  · http://llvm.moe  · http://powerlinesinanime.tumblr.com  · working on quantum computers for a living · DMs open · she

Joined July 2010

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    1. whitequark‏ @whitequark Sep 23

      today i walked for about 1 km. after that, i was gasping for air, didn't feel my legs, had tunnel vision, nearly lost balance, and was simultaneously freezing and sweating. i love antidepressants. sincerely. anxiety before clomipramine was way worse than its side effects

      4 replies 0 retweets 30 likes
      Show this thread
    2.  🐜 💩 💛‏ @ultimape Sep 23
      Replying to @whitequark

      I've seen some that make blood pressure drop while climbing stairs. Fainting + stairs = bad time :(

      1 reply 0 retweets 0 likes
    3. whitequark‏ @whitequark Sep 23
      Replying to @ultimape

      yeah it's one of those too.

      1 reply 0 retweets 0 likes
    4.  🐜 💩 💛‏ @ultimape Sep 23
      Replying to @whitequark

      Any idea what the mechanism might be? I find it odd that not everyone experiences it.

      1 reply 0 retweets 0 likes
    5. whitequark‏ @whitequark Sep 23
      Replying to @ultimape

      these are all anticholinergic side effects. really fucks up your autonomous nervous system. as for not everyone experiencing it, well, no drug ever works exactly the same on two different people

      1 reply 0 retweets 3 likes
    6. Ryan  👻 Pavlik‏ @rpavlik Sep 23
      Replying to @whitequark @ultimape

      Oof, yeah, clomipramine is one of the dirtier ones. Surprised (but happy) it works for your anxiety - I had only heard of it in the context of OCD (as being a fairly potent serotonin reuptake inhibiter) but even for that it's a mixed bag (paradoxical effects anyone?)

      1 reply 0 retweets 0 likes
    7. Ryan  👻 Pavlik‏ @rpavlik Sep 23
      Replying to @rpavlik @whitequark @ultimape

      Neuropsychologist explained once that while ssri's and tca's can effectively be a "cure" for depression, they're not great with anxiety, and anti anxiety meds (benzos,etc) are more of a stop gap measure to get to CBT ideally, since they can make things worse thru conditioning...

      2 replies 0 retweets 0 likes
    8.  🐜 💩 💛‏ @ultimape Sep 23
      Replying to @rpavlik @whitequark

      Interesting: ranking antidepressants by anticholinergic effects also seems to coincide 1:1 to rates of liver failure among susceptible populations. Also trends with side effects of 'enlarged male breasts'. suspected action: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/ … and https://scholar.google.com/scholar?cites=10143175757955727093&as_sdt=5,46&sciodt=0,46&hl=en …

      1 reply 0 retweets 0 likes
      whitequark‏ @whitequark Sep 23
      Replying to @ultimape @rpavlik

      so i get huge boobs instead of anxiety, cool

      12:21 PM - 23 Sep 2018
      2 replies 0 retweets 0 likes
        1. New conversation
        2.  🐜 💩 💛‏ @ultimape Sep 23
          Replying to @whitequark @rpavlik

          Might be related to why Spironolactone can help autism/schizophrenia. If antidepressents are regulating estrogen / testosterone + having knock on effects on dopamine via choline metabolism -> reduced negative symptoms? Solves a lot of oddness in my models of it.

          2 replies 0 retweets 0 likes
        3.  🐜 💩 💛‏ @ultimape Sep 23
          Replying to @ultimape @whitequark @rpavlik

          Tl;DR: It might work in reverse if you're like me and have the High-Androgen version of autism/schziophrenia etiology.

          1 reply 0 retweets 0 likes
        4.  🐜 💩 💛‏ @ultimape Sep 23
          Replying to @ultimape @whitequark @rpavlik

          High androgen can lead to breast in enlargement via similar action to how 'doping' with steroids to build muscle works. Strikes me that the regulatory systems for hormones can get out-of-whack in different ways, over compensating for some, and under compensating for others.

          0 replies 0 retweets 0 likes
        5. End of conversation
        1. Ryan  👻 Pavlik‏ @rpavlik Sep 23
          Replying to @whitequark @ultimape

          Win-win?

          0 replies 0 retweets 0 likes
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