Manuscript describes genomic basis for rapid adaptation to extreme environmental pollution among populations distributed along pollution gradient. It shows that 1) adaptation to urban estuaries is polygenic, and includes adaptive de-sensitization of key signaling pathway…
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…2) two key adaptive variants did not come from the local gene pool – they came from introgression with a different species whose range is >2000 km away. Introgression was RECENT, involved VERY FEW successful migrants, and introgressed variants had HUGE benefit [s=0.8]
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These fish have among the highest levels of nucleotide diversity of any vertebrate species – lots of genetic gas in the tank, so high evolutionary potential. Good enough for adaptation to intermediate pollution, but extreme pollution required cross-species introgression
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Take home: without huge reservoirs of genetic diversity, AND luck with hybridization when that isn’t enough, good luck in the Anthropocene... Most species aren’t like killifish, where evolution is unlikely to keep up with the pace/severity of some human-induced environ. change
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Outstanding collaborative group: Project was the vision of Cole Matson. Data generation by Joe Shaw’s
@genome_explorer group. Heavy lifting for popgen analysis and tox data by Elias Oziolor@eliasoziolor. Initial big discovery of introgression and more by Noah Reid@NM_ReidPrikaži ovu nit -
Kristin Lee
@krstnmlee and Sivan Yair@sivan_yair teamed up to develop new analytical tools to model introgression that offered huge scope for inference. Their cleverness for acronyms (DMC-myAdidas) nearly rivals their computational prowess -https://github.com/kristinmlee/dmc/tree/master/myAdidas …Prikaži ovu nit -
If you hit a paywall, access a copy of the pdf from the WhiteheadLab website:https://whiteheadresearch.wordpress.com/publications/
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Here is an audio/visual narration of the manuscript and figures - e.g., for folks that want to nerd-out while driving to work or while washing the dishes, or for those with challenges accessing texthttps://youtu.be/EWcAK2wQ3XA
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Love this paper. What are the odds... that there was an opportunity for introgression... and that y'all were able to detect it. Very nice!
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Fantastic thread. Thank you Andrew for all of your work, support and mentorship throughout this project!
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