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Lithium is another example of a mood disorder drug that works (really well actually) but nobody knows for certain why:

Lithium: the gripping history of a psychiatric success story

Nature - The treatment for bipolar disorder was discovered through an unlikely route. Douwe Draaisma praises an account of it.

1:08 AM · Jul 22, 2022Twitter Web App

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Something that hasn't been studied properly IMO is that a lot of psychiatric illnesses show up in early adulthood. What exactly is the reason for that? I have some theories, but I've never come across a satisfying explanation