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I draw a distinction between "mass-energy equivalence, the concept described by physicists" and "the way nature works." Our concepts can very accurately describe nature, but they are not the same thing as it. When we speak of "facts" we still speak of concepts.
The amount of human work it takes to say, "this concept is actually an accurate description of nature" is immense and frequently on-going. The concepts do not sustain themselves. (Nature, of course, does. But our awareness is never perfect, and usually incomplete.)
