I parsed that as their criteria excluded children for whom hormone therapy was not being considered. If hormone therapy is not considered until puberty has begun, and most kids at the stage where hormone therapy is considered have mature gametes, then that's the pop we care about
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Replying to @KelseyTuoc
FWIW, it's exceedingly dofficult to figure out what clinicians are actually doing, the guidelines that call for Tanner stage 2 development do *not* indicate mature gametes, and many of these kids are rendering themselves infertile for life. I'm really uncomfortable with this.
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Replying to @webdevMason @KelseyTuoc
AFAICT, spermarche occurs at variable Tanner stages, but often not prior to Tanner stage 3; menarche is typically at Tanner stage 4. I keep trying to not throw myself back into this because there is absolutely nothing for me to gain here, but it is what it is.
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Replying to @webdevMason @KelseyTuoc
Truth be told, there is one correct answer, Kelsey, and you already have it.
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Replying to @webdevMason
Have you found anything indicating that the 96% and 91% numbers are atypical?
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Replying to @webdevMason
"91% of transgender females had progressed beyond Tanner stage 2 and were offered an opportunity to bank sperm; 96% of transgender males were postmenarchal and were offered a referral to a reproductive endocrinologist at a nearby fertility practice."
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Replying to @KelseyTuoc
Tanner stage 2 *is not* confirmatory or disconfirmatory for spermarche. Tanner stage 1 is literally "no signs of puberty," so it doesn't make sense to even consider sperm banking prior to stage 2. Postmenarchal AFAB patients are Tanner stage 4 & in a much better position.
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Replying to @webdevMason
Right, but "beyond Tanner stage 2" presumably means they're stage 3 or later? Agree that "in Tanner stage 2" wouldn't mean much but that's not what the paper says.
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Replying to @KelseyTuoc
I don't know. I read this as "inclusive of Tanner stages 2 and greater." Either way, not indicative of spermarche, though 3 is significantly higher likelihood than 2. Guidelines for suppression of puberty with blockers call for Tanner stage 2 at minimum, AFAB or AMAB.
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> WPATH guidelines recommend Tanner stage 2 at minimum, but notes that some clinics may require stage 3-4 https://www.wpath.org/media/cms/Documents/SOC%20v7/Standards%20of%20Care_V7%20Full%20Book_English.pdf … > Endocrine Society recommends blockers at Tanner stage 2 https://endocrinenews.endocrine.org/blocking-puberty-in-transgender-youth/ … > UCSF says Tanner stage 2-3 is ideal https://transcare.ucsf.edu/guidelines/youth …
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Replying to @webdevMason
Thanks. Changing my mind towards "the guidelines permit transition early enough that the tradeoff with fertility is in fact quite absolute; few transitions actually occur that early but that does not seem to be because guidelines discourage it". WIll email study authors re >=T2.
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Replying to @KelseyTuoc
Curious why you think few transitions happen that early? Presumably not because of this study? I'm finding a number of clinical refs that argue for intervention as close to Tanner 2 as possible & having a hard time finding arguments in favor of delay. Fertility rarely discussed.
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