Trans kids on puberty blockers maintain pretty stable bone density during a period when cis kids rapidly gain bone density. Researchers conclude "there was no significant change in [bone density]," further scans are not needed, and trans kids should have their own reference group https://twitter.com/will_malone/status/1148000551608750080 …
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I parsed that as their criteria excluded children for whom hormone therapy was not being considered. If hormone therapy is not considered until puberty has begun, and most kids at the stage where hormone therapy is considered have mature gametes, then that's the pop we care about
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My understanding is that the current standard of care involves letting puberty start a little, because some prepubescent dysphoria desists when puberty begins, and then aggressive treatment if the dysphoria does not desist. That means the treated pop is not prepubescent.
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